Naoufal Zamzami

TL;DR: The identification and cloning of an apoptosis-inducing factor, AIF, which is sufficient to induce apoptosis of isolated nuclei is reported, indicating that AIF is a mitochondrial effector of apoptotic cell death.

TL;DR: Assessment of mitochondrial ROS generation provides an accurate picture of PCD-mediated lymphocyte depletion and indicates alterations of mitochondrial function constitute an important feature of early PCD.

TL;DR: It is demonstrated that mitochondrial membrane permeabilization (MMP) constitutes a decisive step of the apoptotic process, and several apoptogenic proteins normally confined to mitochondria are released in the extra-mitochondrial space and participate in the suicidal dismantling of the cell.

TL;DR: Direct evidence is presented indicating that mitochondrial PT constitutes a critical early event of the apoptotic process, and a specific ligand of the mitochondrial adenine nucleotide translocator, bongkreik acid, inhibits PT and reduces apoptosis induction by mitochondria in a cell-free system.

TL;DR: It is shown that genetic inactivation of AIF renders embryonic stem cells resistant to cell death after serum deprivation, providing genetic evidence for a caspase-independent pathway of programmed cell death that controls early morphogenesis.