Bryan Hassell

TL;DR: This Review outlines how recent developments in microfluidic cell culture technology have led to the generation of human organs-on-chips that are now being used to model cancer cell behaviour within human-relevant tissue and organ microenvironments in vitro.

TL;DR: E engineered in vitro models of diseases of the heart, lung, intestine, liver, kidney, cartilage, skin and vascular, endocrine, musculoskeletal, and nervous systems, as well as models of infectious diseases and cancer are provided.

TL;DR: Use of the mechanical actuation functionalities of microfluidic organ-on-a-chip (organ chip) cell culture technology revealed a previously unknown sensitivity of lung cancer cell growth, invasion, and TKI therapeutic responses to physical cues associated with breathing motions, which appear to be mediated by changes in signaling through epidermal growth factor receptor (EGFR) and MET protein kinase.

TL;DR: A microfluidic device for the quantitative measurements of oocyte volume during various CPA loading protocols is developed and it is believed this single oocyte analysis technology will eventually help future advances in assisted reproductive technologies and fertility preservation.

TL;DR: Blinded, retrospective analysis of clinical data and neutrophil migration parameters revealed that neutrophils isolated from blood samples collected during sepsis migrate spontaneously inside the microfluidic channels.