Esak Lee

TL;DR: Use of the mechanical actuation functionalities of microfluidic organ-on-a-chip (organ chip) cell culture technology revealed a previously unknown sensitivity of lung cancer cell growth, invasion, and TKI therapeutic responses to physical cues associated with breathing motions, which appear to be mediated by changes in signaling through epidermal growth factor receptor (EGFR) and MET protein kinase.

TL;DR: This study demonstrates anti-metastatic activities of multiple repurposed drugs, blocking a self-reinforcing paracrine loop between breast cancer cells and LECs.

TL;DR: A mechanotransduction pathway is identified that translates laminar flow–induced shear stress to activation of lymphatic sprouting in blood endothelial cells and lymphatic endothelial Cells (LECs).

TL;DR: This tumor-on-a-chip model provides an important in vitro platform for investigating the process of PDAC-driven endothelial ablation and may provide a mechanism for tumor hypovascularity.

TL;DR: It is suggested that BEC and LEC in various microenvironments can be orchestrators of tumour progression and proposes new mechanism-based strategies to discover new therapies to supplement conventional anti-angiogenic and anti-lymphangiogens therapies.