C
C. A. A. Van Boeckel
Researcher at Organon International
Publications - 138
Citations - 3814
C. A. A. Van Boeckel is an academic researcher from Organon International. The author has contributed to research in topics: Antithrombin & Heparin. The author has an hindex of 34, co-authored 138 publications receiving 3735 citations. Previous affiliations of C. A. A. Van Boeckel include Leiden University.
Papers
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Journal ArticleDOI
Chiral selection in poly(C)-directed synthesis of oligo(G)
Gerald F. Joyce,G. M. Visser,C. A. A. Van Boeckel,J. H. Van Boom,Leslie E. Orgel,J. van Westrenen +5 more
TL;DR: It is reported here that poly(C)-directed oligomerization of activated guanosine mononucleotides proceeds readily if the monomers are of the same optical handedness as the template, and is indeed far less efficient if theMonomers of the opposite handedness are involved.
Journal ArticleDOI
Biochemical and pharmacological properties of SANORG 34006, a potent and long-acting synthetic pentasaccharide
J.M. Herbert,J. P. Herault,A Bernat,van Rgm Amsterdam,J.C. Lormeau,M Petitou,C. A. A. Van Boeckel,Peter R. Hoffmann,D.G. Meuleman +8 more
TL;DR: It is suggested that SANORG 34006 is a promising compound in the treatment and prevention of various thrombotic diseases.
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Use of the cationic iridium complex 1,5-cyclooctadiene-bis(methyldiphenylphosphine)-iridium hexafluorophosphate in carbohydrate chemistry: smooth isomerization of allyl ethers to 1-propenyl ethers
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Synthesis of a Pentasaccharide Corresponding to the Antithrombin III Binding Fragment of Heparin
C. A. A. Van Boeckel,T. Beetz,J. N. Vos,A. J. M. De Jong,S. F. Van Aelst,R. H. van den Bosch,J. M. R. Mertens,F. A. Van Der Vlugt +7 more
TL;DR: The synthesis of a protected pentasaccharide 27b corresponding to the antithrombin III binding region of heparin is presented, protected with acetyl at the positions to be sulphated, benzyl at other hydroxyl functions and azide at the 2-position of the glucosamine residues.
Journal ArticleDOI
A new approach to the synthesis of phosphotriester intermediates of nucleosides and nucleic acids
TL;DR: Aryl phosphorodichloridates can be converted by means of 1-hydroxybenzotriazole into an effective phosphorylating agent, which can be applied to the synthesis of phosphotriester intermediates of nucleic acids as mentioned in this paper.