C
C.A. Reynaud
Researcher at Paris Descartes University
Publications - 8
Citations - 966
C.A. Reynaud is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Somatic hypermutation & Immunoglobulin M. The author has an hindex of 6, co-authored 8 publications receiving 915 citations. Previous affiliations of C.A. Reynaud include French Institute of Health and Medical Research.
Papers
More filters
Journal ArticleDOI
Human blood IgM “memory” B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire
Sandra K. Weller,Moritz C. Braun,Bruce K. Tan,Andreas Rosenwald,Corinne Cordier,Mary Ellen Conley,Alessandro Plebani,D S Kumararatne,Damien Bonnet,Olivier Tournilhac,Gil Tchernia,Birte Steiniger,Louis M. Staudt,Jean-Laurent Casanova,C.A. Reynaud,J.C. Weill +15 more
TL;DR: It is proposed that these IgM(+)IgD(+)CD27(+) B cells provide the splenic marginal zone with a diversified and protective preimmune repertoire in charge of the responses against encapsulated bacteria.
Journal ArticleDOI
IgM+IgD+CD27+ B cells are markedly reduced in IRAK-4-, MyD88- and TIRAP- but not UNC-93B-deficient patients
Sandra K. Weller,Mélanie Bonnet,Héloïse Delagreverie,Laura Israel,Maya Chrabieh,László Maródi,Carlos Rodríguez-Gallego,Ben Zion Garty,Chaim M. Roifman,Andrew C. Issekutz,Simona Eva Zitnik,Cyrille Hoarau,Yildiz Camcioglu,Júlia Vasconcelos,Carlos Rodrigo,Peter D. Arkwright,Andrea Cerutti,Andrea Cerutti,Eric Meffre,Shen-Ying Zhang,Shen-Ying Zhang,Alexandre Alcaïs,Anne Puel,Jean-Laurent Casanova,Jean-Laurent Casanova,Capucine Picard,J.C. Weill,C.A. Reynaud +27 more
TL;DR: A role is proposed for TIRAP-dependent TLRs, possibly TLR10 in particular, in the development and/or maintenance of IgM(+)IgD(+)CD27(+) B cells in humans.
Journal ArticleDOI
Competitive repair pathways in immunoglobulin gene hypermutation
TL;DR: The proposition that the UNG uracil glycosylase and the MSH2–MSH6 mismatch recognition complex are two competitive rather than alternative pathways in the processing of uracils generated by AID is further discussed.
Journal ArticleDOI
A splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responses.
Simon Le Gallou,Zhicheng Zhou,Lan Huong Thai,Rémi Fritzen,Alba Verge de los Aires,Jérôme Mégret,Philipp Yu,Daisuke Kitamura,Emmanuelle Bille,Emmanuelle Bille,Fabiola Tros,Xavier Nassif,Xavier Nassif,Alain Charbit,Sandra K. Weller,J.C. Weill,C.A. Reynaud +16 more
TL;DR: It is described here, based on an inducible AID fate-mapping mouse model, that systemic memory B cell subsets, including mainly IgM+ B cells inSpleen, together with IgA+ plasma cells in spleen and bone marrow, are generated in mice in the absence of deliberate immunization.
Book ChapterDOI
Ig gene hypermutation: a mechanism is due.
Jean Claude Weill,Barbara Bertocci,Ahmad Faili,Said Aoufouchi,Stéphane Frey,De Smet A,Sébastien Storck,Auriel Dahan,Frédéric Delbos,Sandra K. Weller,Eric Flatter,C.A. Reynaud +11 more
TL;DR: This chapter reviews the possible participation of some mismatch repair (MMR) components, the mammalian MutS-homologs, the role of Ig gene transcription in the targeting of the process, the occurrence of DNA breaks as specific priming events, the involvement of an error-prone DNA polymerase and the emergence of several new candidate enzymes, and a new partner.