A
Andrea Cerutti
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 164
Citations - 14563
Andrea Cerutti is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Immunoglobulin class switching & Immune system. The author has an hindex of 54, co-authored 155 publications receiving 13020 citations. Previous affiliations of Andrea Cerutti include Pasteur Institute & Mount Sinai Hospital.
Papers
More filters
Journal ArticleDOI
DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
Mikhail B. Litinskiy,Bernardetta Nardelli,David M. Hilbert,Bing He,András Schaffer,Paolo Casali,Andrea Cerutti +6 more
TL;DR: By eliciting CD40-independent Ig class switching and plasmacytoid differentiation, BLyS and APRIL critically link the innate and adaptive immune responses.
Journal ArticleDOI
Intestinal Bacteria Trigger T Cell-Independent Immunoglobulin A2 Class Switching by Inducing Epithelial-Cell Secretion of the Cytokine APRIL
Bing He,Weifeng Xu,Paul A. Santini,Alexandros D. Polydorides,April Chiu,Jeannelyn Santiano Estrella,Meimei Shan,Amy Chadburn,Vincenzo Villanacci,Alessandro Plebani,Daniel M. Knowles,Maria Rescigno,Andrea Cerutti +12 more
TL;DR: The authors' data indicate that bacteria elicit IgA(2) class switching by linking lamina propria B cells with IECs through a TLR-inducible signaling program requiring APRIL.
Journal ArticleDOI
B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen
Irene Puga,Montserrat Cols,Carolina M. Barra,Bing-Yang He,Linda Cassis,Maurizio Gentile,Laura Comerma,Alejo Chorny,Meimei Shan,Weifeng Xu,Giuliana Magri,Daniel M. Knowles,Wayne Tam,April Chiu,James B. Bussel,Sergi Serrano,José Antonio Lorente,Beatriz Bellosillo,Josep Lloreta,Nuria Juanpere,Francesc Alameda,Teresa Baró,Cristina Díaz de Heredia,Nuria Toran,Albert Català,Montserrat Torrebadell,Claudia Fortuny,Victoria Cusí,Carmen Carreras,George A. Diaz,J. Magarian Blander,Claire-Michèle Farber,Guido Silvestri,Charlotte Cunningham-Rundles,Michaela Calvillo,Carlo Dufour,Lucia Dora Notarangelo,Vassilios Lougaris,Alessandro Plebani,Jean-Laurent Casanova,Stephanie C. Ganal,Andreas Diefenbach,Juan I. Aróstegui,Manel Juan,Jordi Yagüe,Nizar Mahlaoui,Jean Donadieu,Kang Chen,Andrea Cerutti +48 more
TL;DR: Neutrophils around the marginal zone (MZ) of the spleen, a B cell area specialized in T cell–independent immunoglobulin responses to circulating antigen, are identified, which indicates that neutrophils generate an innate layer of antimicrobial immunoglOBulin defense by interacting with MZ B cells.
Journal ArticleDOI
Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes
TL;DR: This Review discusses how marginal zone B cells function as innate-like lymphocytes that mount rapid antibody responses to both T cell-dependent and Tcell-independent antigens.
Journal ArticleDOI
The regulation of IgA class switching
TL;DR: Recent advances indicating that innate immune recognition of microbial signatures at the epithelial-cell barrier is central to the selective induction of mucosal IgA class switching are described.