M
Matthew R. Livesey
Researcher at University of Edinburgh
Publications - 43
Citations - 1537
Matthew R. Livesey is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Induced pluripotent stem cell & Cellular differentiation. The author has an hindex of 19, co-authored 40 publications receiving 1184 citations. Previous affiliations of Matthew R. Livesey include University of Sheffield & University of Dundee.
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Journal ArticleDOI
Modeling ALS with motor neurons derived from human induced pluripotent stem cells.
Samuel Sances,Lucie Bruijn,Siddharthan Chandran,Kevin Eggan,Ritchie Ho,Joseph R. Klim,Matthew R. Livesey,Emily Rhodes Lowry,Jeffrey D. Macklis,David Rushton,Cameron Sadegh,Dhruv Sareen,Hynek Wichterle,Su-Chun Zhang,Clive N. Svendsen +14 more
TL;DR: Common developmental principles of both lower and upper motor neuron development that have led to specific derivation techniques are discussed and how these motor neurons may be matured further either through direct expression or administration of specific factors or coculture approaches with other tissues are suggested.
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Influence of GluN2 subunit identity on NMDA receptor function
TL;DR: Some recent studies that have identified structural elements within GluN2 subunits that contribute to the heterogeneous biophysical properties of NMDARs are highlighted, and why some recently described novel pharmacological tools may permit better identification of native N MDAR subtypes are considered.
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C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity
Bhuvaneish T. Selvaraj,Matthew R. Livesey,Chen Zhao,Jenna M. Gregory,Owain T. James,Elaine M. Cleary,Amit K. Chouhan,Amit K. Chouhan,Angus B. Gane,Emma M. Perkins,Owen Dando,Simon G. Lillico,Youn-Bok Lee,Agnes L. Nishimura,Urjana Poreci,Sai Thankamony,Meryll Pray,Navneet A. Vasistha,Dario Magnani,Shyamanga Borooah,Karen Burr,David Story,Alexander McCampbell,Christopher Shaw,Peter C. Kind,Timothy J. Aitman,C. Bruce A. Whitelaw,Ian Wilmut,Colin Smith,Gareth B. Miles,Gareth B. Miles,Giles E. Hardingham,David J. A. Wyllie,Siddharthan Chandran +33 more
TL;DR: It is shown that increased expression of GluA1 AMPA receptor (AMPAR) subunit occurs in MNs with C9ORF72 mutations that leads to increased Ca2+-permeable AMPAR expression and results in enhanced selective MN vulnerability to excitotoxicity.
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Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes
Philip E. Chen,Matthew T. Geballe,Elyse Katz,Kevin Erreger,Matthew R. Livesey,Kate K. O'Toole,Phuong Le,C. Justin Lee,James P. Snyder,Stephen F. Traynelis,David J. A. Wyllie +10 more
TL;DR: It is concluded that the variation in glycine potency is caused by interactions between the NR1 and NR2 ligand‐binding domains that occur following agonist binding and which may be involved in the initial conformation changes that determine channel gating.
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Maturation and electrophysiological properties of human pluripotent stem cell-derived oligodendrocytes
Matthew R. Livesey,Dario Magnani,Elaine M. Cleary,Navneet A. Vasistha,Owain T. James,Bhuvaneish T. Selvaraj,Karen Burr,David Story,Christopher Shaw,Peter C. Kind,Giles E. Hardingham,David J. A. Wyllie,Siddharthan Chandran +12 more
TL;DR: It is established that the development of human oligodendroglia membrane properties closely resemble those found in rodent cells and have generated a platform to enable the impact of human neurodegenerative disease‐causing mutations on oligod endodendrocyte maturation to be studied.