Showing papers in "Trends in Biotechnology in 2018"

TL;DR: This review comprehensively describes the current research on the possible roles and applications of microalgae for removing PCs from aqueous media and summarizes several novel approaches including constructing microbial consortia, acclimation, and cometabolism for enhanced removal of PCs by microalgal.

TL;DR: Recently, biomimetic wound dressings were introduced as potential replacements for treating skin injuries and silk fibroin (SF) has exceptional characteristics as a wound dressing.

TL;DR: The potential of nanoparticles as an optimal platform to deliver biomolecules to plants for genetic engineering is discussed, owing to their ability to traverse plant cell walls without external force and highly tunable physicochemical properties for diverse cargo conjugation and broad host range applicability.

TL;DR: The salient features, the hurdles that must be overcome, and the hopes and constraints for the development of BGs with improved angiogenetic properties are introduced.

TL;DR: Current strategies available for in vivo delivery of CRISPR-Cas gene editing components are reviewed and challenges that need to be addressed are outlined before this powerful tool can be deployed in the clinic.

TL;DR: The current status, emerging issues, regulatory context, and opportunities of cold plasma with respect to the broad stages of primary and secondary food production are presented.

TL;DR: The state of the art on the design and use of biocatalysis in flow reactors is described, highlighting new opportunities, problems to be solved and technological advances.

TL;DR: This opinion article discusses the emergence of a third strategy in TE that integrates the advantages of both of these traditional approaches, while being clearly distinct from them.

TL;DR: It is emphasized that obtaining a good-quality bioink depends on the choice of organ, animal, and decellularization method, and potential large-scale applications of bioinks and challenges in manufacturing such bioinks are explored.

TL;DR: The interactions among multiple target pollutants and the changes in the bioavailability and biodegradability of substrates that are responsible for substrate interactions are reviewed, and potential strategies for enhancing biofilter performance are discussed.

TL;DR: This work discusses strategies to reverse-engineer and recombine functional parts for synthetic eukaryotes, mimicking the characteristics of nature’s own prototype, and identifies microfluidics and DNA nanotechnology as two technologies that can integrate these functional modules into sophisticated multifunctional synthetic cells.

TL;DR: This Opinion article focuses on the use of genome editing to target S genes for the development of transgene-free and durable disease-resistant crop varieties.

TL;DR: This work highlights the advantages, challenges, and translational potential of tumor organoids in personalized cancer therapy and focuses on gene-drug associations, drug response prediction, and treatment selection, and how microfluidic technology can contribute to immunotherapy drug screening in tumor organoid.

TL;DR: In this paper, the authors present strategies inspired from high-throughput screening techniques implemented in drug discovery to exploit the potential of a growing cell-adhesion peptide library, which in turn could lead to improved cell culture models, implants, and wound dressings.

TL;DR: Technologies that have been developed to actively monitor the wound environment are discussed and drug delivery tools that have be integrated with bandages to facilitate precise temporal and spatial control over drug release are highlighted.

TL;DR: This opinion paper aims to introduce strategies for systematic debugging of nano-bio interfaces in the current literature to minimize the bench-to-clinic gap between the efforts and effective clinical translation of NPs.

TL;DR: This review focuses on recent in vivo studies demonstrating potential therapeutic uses of catalytic nanomaterials, and provides insights about the relationships between catalytic activity, therapeutic efficacy, and biocompatibility that are critical for clinical translatability.

TL;DR: Some new applications for plasma in cancer therapy based on plasma self-organization, which enables adaptive features in plasma-based therapeutic systems, are discussed.

TL;DR: Using effluents from biogas production units, called digestates, in cultivation systems can help to optimize bioprocesses, and several bioproducts including biofuels, biofertilizers, proteins and valuable chemicals can be obtained.

TL;DR: The approaches that have been developed to facilitate single-cell DNA methylation profiling, their biological applications, and how these will further the understanding of the biology ofDNA methylation are reviewed.

TL;DR: The unique opportunities and challenges for translating CAP to the management of biofilms are reviewed, and the importance of understanding interactions and physiological responses to CAP exposure are central to effective management of infectiousBiofilms.

TL;DR: The challenges of systemic delivery of si RNA-based therapy for brain diseases are outlined, recent advances in the development and engineering of siRNA nanomedicines for various brain diseases is highlighted, and perspectives on this exciting research field for siRNA- based therapy towards more effective brain disease therapy are discussed.

TL;DR: The biodiversity of microbial biosurfactants produced in cold habitats is reviewed and a perspective on the most promising future applications in environmental and industrial technologies is provided.

TL;DR: This work highlights the opportunities and challenges for managing microbial aggregates in wastewater treatment to remove or control NPs, and explains how aggregation stabilizes a complex microbial ecosystem that enhances the ability of the community to adapt to prolonged NP exposure.

TL;DR: Imaging flow cytometry is seeing a paradigm shift from low- to high-information-content analysis, driven partly by deep learning algorithms, and a wealth of applications with potential translation into clinical practice are predicted.

TL;DR: In insights into the further development of polymeric carriers with enhanced efficiency in transfection, a review of the latest strategies to enhance the intracellular delivery process is provided.

TL;DR: This review highlights multiomics studies that elucidate the mechanisms allowing this yeast to achieve lipid overaccumulation and then presents several major metabolic engineering efforts that enhanced the production metrics in Y. lipolytica.

TL;DR: This review investigates recent developments in metabolic engineering and describes how the new tools being developed help to realize the full industrial potential of the oleaginous yeast Yarrowia lipolytica.

TL;DR: This review discusses the preparation and biological evaluation of fluorescent antibiotics, focussing on how these reporters and assay methods can help elucidate resistance mechanisms and the potential utility of such probes for real-time in vivo diagnosis of infections.

TL;DR: This review highlights specific examples where organic electronic materials solve multiple issues related to complex sensing environments, and benchmark these examples by comparing them to state-of-the-art commercially available sensing using alternative technologies.