C
C. Colin Brinkman
Researcher at University of Maryland, Baltimore
Publications - 26
Citations - 721
C. Colin Brinkman is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 16, co-authored 25 publications receiving 564 citations. Previous affiliations of C. Colin Brinkman include University of Virginia Health System & University of Virginia.
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Journal ArticleDOI
Incomplete Differentiation of Antigen-Specific CD8 T Cells in Tumor-Draining Lymph Nodes
Kristian M. Hargadon,C. Colin Brinkman,Stacey L. Sheasley-O’Neill,Lisa A. Nichols,Timothy N. J. Bullock,Victor H. Engelhard +5 more
TL;DR: Activated T cells lacking effector function develop through incomplete differentiation in the lymph nodes of late-stage tumor-bearing mice, rather than through suppression of previously differentiated cells.
Journal ArticleDOI
CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration
Yanbao Xiong,Wenji Piao,C. Colin Brinkman,Lushen Li,Joseph M. Kulinski,Ana Olivera,Andreane Cartier,Andreane Cartier,Timothy Hla,Timothy Hla,Keli L. Hippen,Bruce R. Blazar,Susan R. Schwab,Jonathan S. Bromberg +13 more
TL;DR: Different roles for S1PRs are demonstrated in comodulating T cell and LEC functions in migration and suggest previously unknown levels of regulation of leukocytes and endothelial cells during homeostasis and immunity.
Journal ArticleDOI
Regulatory T cell induction, migration, and function in transplantation.
TL;DR: Critical analyses suggest that key factors in Treg induction, migration, and function are important areas to concentrate investigative efforts and therapeutic development.
Journal ArticleDOI
Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration
C. Colin Brinkman,Daiki Iwami,Molly K. Hritzo,Yanbao Xiong,Sarwat B. Ahmad,Thomas Simon,Keli L. Hippen,Bruce R. Blazar,Jonathan S. Bromberg +8 more
TL;DR: A form of T-cell migration used only by Treg in tissues that serves an important role in their suppressive function and is a unique therapeutic focus for modulating suppression is demonstrated.
Journal ArticleDOI
Gut microbiota–dependent modulation of innate immunity and lymph node remodeling affects cardiac allograft outcomes
Jonathan S. Bromberg,Lauren E. Hittle,Yanbao Xiong,Vikas Saxena,Eoghan M. Smyth,Lushen Li,Tianshu Zhang,Chelsea Wagner,W. Florian Fricke,Thomas Simon,C. Colin Brinkman,Emmanuel F. Mongodin +11 more
TL;DR: Analysis of mesenteric and peripheral lymph node structure showed that B. pseudolongum gavage resulted in a higher laminin α4/α5 ratio in the lymph node cortical ridge, indicative of a suppressive environment, while D. desulfuricans results in a lower lamination ratio, supportive of inflammation.