P
P. G. Nantermet
Researcher at Scripps Research Institute
Publications - 6
Citations - 1239
P. G. Nantermet is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Semisynthesis & Baccatin III. The author has an hindex of 5, co-authored 6 publications receiving 1163 citations. Previous affiliations of P. G. Nantermet include University of California, San Diego.
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Journal ArticleDOI
Total synthesis of taxol
Kyriacos C. Nicolaou,Kyriacos C. Nicolaou,Zhen Yang,J. J. Liu,H. Ueno,P. G. Nantermet,R. K. Guy,Christopher F. Claiborne,J. Renaud,Elias A. Couladouros,K. Paulvannan,Erik J. Sorensen,Erik J. Sorensen +12 more
TL;DR: The total synthesis of taxol is reported by a convergent strategy, which opens a chemical pathway for the production of both the natural product itself and a variety of designed taxoids.
Journal ArticleDOI
Total Synthesis of Taxol. 2. Construction of A and C Ring Intermediates and Initial Attempts To Construct the ABC Ring System
Kyriacos C. Nicolaou,Jia Liu,Zhen Yang,H. Ueno,Erik J. Sorensen,Christopher F. Claiborne,R. K. Guy,C.-K. Hwang,Masahisa Nakada,P. G. Nantermet +9 more
Journal ArticleDOI
Total synthesis of taxol.
Kyriacos C. Nicolaou,Kyriacos C. Nicolaou,Zhen Yang,J. J. Liu,H. Ueno,P. G. Nantermet,R. K. Guy,Christopher F. Claiborne,J. Renaud,Elias A. Couladouros,K. Paulvannan,Erik J. Sorensen,Erik J. Sorensen +12 more
TL;DR: Taxol, a substance originally isolated from the Pacific yew tree (Taxus brevifolia) more than two decades ago, has recently been approved for the clinical treatment of cancer patients as mentioned in this paper.
Journal ArticleDOI
Novel chemistry of taxol. Retrosynthetic and synthetic studies
TL;DR: 10-Deacetyl baccatin III 2 was used in the synthesis of compounds 4–6 and 11–15, all of which were converted to Taxol 1via efficient synthetic pathways.