C. Preston Neff

TL;DR: A series of new dual inhibitory function anti-gp120 aptamer–siRNA chimeras are created and a ‘sticky’ sequence is introduced onto a chemically synthesized aptamer which facilitates attachment of the Dicer substrate siRNAs for potential multiplexing.

TL;DR: Interleukin-1 family members are highly inflammatory but IL-37 member broadly suppresses inflammation and specific immunity and acts as an extracellular cytokine by binding to the IL-18 receptor but using theIL-1R8 for its anti-inflammatory properties.

TL;DR: The in vivo efficacy of structurally flexible, cationic PAMAM dendrimers as a small interfering RNA (siRNA) delivery system in a Rag2(-)/-γc-/- (RAG-hu) humanized mouse model for HIV-1 infection is evaluated and these data demonstrate for the first time efficacious combinatorial delivery of anti-host and -viral siRNAs for AIDS treatment in vivo.

TL;DR: It is shown that this aptamer-bridge-construct complexed with three different Dicer substrate siRNAs (DsiRNAs) results in effective delivery of the cocktail of DSIRNAs in vivo, resulting in knockdown of target mRNAs and potent inhibition of HIV-1 replication.

TL;DR: Two new classes of clinically approved drugs with different modes of action namely, an integrase inhibitor raltegravir and a CCR5 inhibitor maraviroc are evaluated as potential systemically administered chemo-prophylactics and show great promise for further development as orally administered PrEPs.