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Yuanyu Huang
Researcher at Beijing Institute of Technology
Publications - 102
Citations - 5159
Yuanyu Huang is an academic researcher from Beijing Institute of Technology. The author has contributed to research in topics: Small interfering RNA & Chemistry. The author has an hindex of 31, co-authored 78 publications receiving 3225 citations. Previous affiliations of Yuanyu Huang include Hunan University & Peking University.
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Journal ArticleDOI
Therapeutic siRNA: state of the art.
TL;DR: In this review, the evolution of siRNA chemical modifications and their biomedical performance are comprehensively reviewed and all clinically explored and commercialized siRNA delivery platforms, including the GalNAc–siRNA conjugate, and their fundamental design principles are thoroughly discussed.
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Enhanced Gene Delivery and siRNA Silencing by Gold Nanoparticles Coated with Charge-Reversal Polyelectrolyte
Shutao Guo,Yuanyu Huang,Qiao Jiang,Yun Sun,Liandong Deng,Zicai Liang,Quan Du,Jinfeng Xing,Yuliang Zhao,Paul C. Wang,Anjie Dong,Xing-Jie Liang +11 more
TL;DR: The results demonstrate the feasibility of using charge-reversal functional gold nanoparticles as a means of improving the nucleic acid delivery efficiency.
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Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics
TL;DR: This review covers the progress of GalNAc-decorated oligonucleotide drugs, including siRNAs, anti-miRs, and ASOs, which provides a panorama for this field.
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Multifunctional aptamer-based nanoparticles for targeted drug delivery to circumvent cancer resistance.
Juan Liu,Tuo Wei,Jing Zhao,Yuanyu Huang,Hua Deng,Anil Kumar,Chenxuan Wang,Zicai Liang,Xiaowei Ma,Xing-Jie Liang +9 more
TL;DR: Functional DNA nanostructure designed and developed to deliver the chemotherapy drug doxorubicin (Dox) to resistant cancer cells provides new insights into the design of nanocarriers to overcome multidrug resistance through targeted drug delivery.
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The challenge and prospect of mRNA therapeutics landscape.
Yuhua Weng,Chunhui Li,Tongren Yang,Bo Hu,Mengjie Zhang,Shuai Guo,Haihua Xiao,Xing-Jie Liang,Yuanyu Huang +8 more
TL;DR: The structural properties and modification technologies of mRNA are described, the latest advances in developing mRNA delivery systems are summarized, the preclinical and clinical applications are reviewed, and the views on the prospect and challenges of developing mRNA into a new class of drug are put forward.