C
C. Wim Ang
Researcher at Erasmus University Rotterdam
Publications - 17
Citations - 1488
C. Wim Ang is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Campylobacter jejuni & Campylobacter. The author has an hindex of 14, co-authored 16 publications receiving 1383 citations. Previous affiliations of C. Wim Ang include Erasmus University Medical Center & VU University Medical Center.
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Journal ArticleDOI
The Guillain–Barré syndrome: a true case of molecular mimicry
TL;DR: It is argued that GBS should be considered as an excellent paradigm and an attractive model for elucidation of both host and microbial aspects of molecular mimicry.
Journal ArticleDOI
The crucial role of Campylobacter jejuni genes in anti-ganglioside antibody induction in Guillain-Barré syndrome
Peggy C. R. Godschalk,Astrid P. Heikema,Michel Gilbert,Tomoko Komagamine,C. Wim Ang,Jobine Glerum,Denis Brochu,Jianjun Li,Nobuhiro Yuki,Bart C. Jacobs,Alex van Belkum,Hubert P. Endtz +11 more
TL;DR: It is demonstrated, for the first time, to the knowledge, that specific bacterial genes are crucial for the induction of anti-ganglioside antibodies.
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Structural Characterization of Campylobacter jejuni Lipooligosaccharide Outer Cores Associated with Guillain-Barré and Miller Fisher Syndromes
Peggy C. R. Godschalk,Mark L. Kuijf,Jianjun Li,Frank St. Michael,C. Wim Ang,Bart C. Jacobs,Marie-France Karwaski,Denis Brochu,Ali Moterassed,Hubert P. Endtz,Alex van Belkum,Michel Gilbert +11 more
TL;DR: It is concluded that molecular mimicry between gangliosides and C. jejuni LOS is the presumable pathogenic mechanism in most cases of C.Jejuni-related Guillain-Barré syndrome, however, the findings suggest that in some cases, other mechanisms may play a role.
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Bacterial peptidoglycan and immune reactivity in the central nervous system in multiple sclerosis
Ingrid A. Schrijver,Marjan van Meurs,Marie-José Melief,C. Wim Ang,Dragan Buljevac,Rivka Ravid,Maarten P. Hazenberg,Jon D. Laman +7 more
TL;DR: It is demonstrated that peptidoglycan is present within antigen-presenting cells in the brain of multiple sclerosis patients, and may contribute to T- and B-cell activity during brain inflammation without a requirement for local bacterial replication.
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Clinical features and response to treatment in Guillain-Barré syndrome associated with antibodies to GM1b ganglioside.
Nobuhiro Yuki,C. Wim Ang,Michiaki Koga,Bart C. Jacobs,Pieter A. van Doorn,Koichi Hirata,Frans G. A. van der Meché +6 more
TL;DR: The distinctive clinical features of the patients with anti‐GM1b antibodies show that acute motor neuropathy represents a specific subgroup within GBS and that recognizing these patients may have consequences as to the choice of therapy.