R
R.A. Floto
Researcher at University of Cambridge
Publications - 10
Citations - 1759
R.A. Floto is an academic researcher from University of Cambridge. The author has contributed to research in topics: Autophagy & Mycobacterium abscessus. The author has an hindex of 4, co-authored 10 publications receiving 1565 citations. Previous affiliations of R.A. Floto include Papworth Hospital.
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Journal ArticleDOI
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
Andrea Williams,Sovan Sarkar,Paul Cuddon,Evangelia K. Ttofi,Shinji Saiki,Farah H. Siddiqi,Luca Jahreiss,Angeleen Fleming,Dean Pask,Paul Goldsmith,Cahir J. O'Kane,R.A. Floto,David C. Rubinsztein +12 more
TL;DR: A cyclical mTOR-independent pathway regulating autophagy is revealed, in which cAMP regulates IP3 levels, influencing calpain activity, which completes the cycle by cleaving and activating G(s)alpha, which regulates cAMP levels.
Journal ArticleDOI
Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies
TL;DR: Various drugs and pathways inducing autophagy, which may be potential therapeutic approaches for Huntington's disease and related conditions are described.
Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium
Josephine M. Bryant,Dorothy M Grogono,Daniela Rodriguez-Rincon,Isobel Everall,Karen Brown,Pablo Moreno,Deepshikha Verma,E. Hill,J. Drijkoningen,Peter H. Gilligan,Charles R. Esther,Peadar G. Noone,Olivia Giddings,Scott C. Bell,Rachel Thomson,Claire E. Wainwright,Chris Coulter,Sushil Pandey,Michelle Wood,Rebecca E Stockwell,Kay A. Ramsay,Laura J. Sherrard,Timothy J. Kidd,Nassib Jabbour,Graham R. Johnson,Luke D. Knibbs,Lidia Morawska,Peter D. Sly,Alison Jones,Diana Bilton,Ian F. Laurenson,Michael Ruddy,Stephen Bourke,Ian C. J. W. Bowler,Stephen J Chapman,Andrew Clayton,M. Cullen,Owen J. Dempsey,Miles Denton,M. Desai,R. J. Drew,F. Edenborough,Jason T. Evans,Jonathan Folb,T. Daniels,H. Humphrey,B. Isalska,Søren Jensen-Fangel,Bodil Jönsson,Andrew Jones,Terese L. Katzenstein,Troels Lillebaek,Gordon MacGregor,S. Mayell,Michael Millar,Deborah E. Modha,Edward F. Nash,C. O'Brien,D. OBrien,Chandra Ohri,Caroline S. Pao,Daniel Peckham,Felicity Perrin,Audrey Perry,Tacjana Pressler,L. Prtak,Tavs Qvist,A. Robb,Helen Rodgers,K. Schaffer,Nadia Shafi,J. van Ingen,M. Walshaw,D. Watson,Noreen West,Joanna L. Whitehouse,Charles S. Haworth,Simon R. Harris,Diane J. Ordway,Julian Parkhill,R.A. Floto +80 more
TL;DR: In this paper, the authors used whole-genome analysis of a global collection of clinical isolates to show that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones.
Journal ArticleDOI
Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion
Mark Schiebler,Karen Brown,Karen Brown,Krisztina Hegyi,Sandra M. Newton,Maurizio Renna,Lucy Hepburn,Catherine Klapholz,Sarah Coulter,Andrés Obregón-Henao,Marcela Henao Tamayo,Randall J. Basaraba,Beate Kampmann,Katherine M. Henry,Joseph Burgon,Stephen A. Renshaw,Angeleen Fleming,Robert R. Kay,Karen E. Anderson,Phillip T. Hawkins,Diane J. Ordway,David C. Rubinsztein,R.A. Floto,R.A. Floto +23 more
TL;DR: It is shown that carbamazepine induces antimicrobial autophagy through a novel, evolutionarily conserved, mTOR‐independent pathway controlled by cellular depletion of myo‐inositol, and in mice infected with a highly virulent multidrug‐resistant MTB strain, carbazepine treatment reduced bacterial burden, improved lung pathology and stimulated adaptive immunity.