F
Francesco Scaravilli
Researcher at University College London
Publications - 156
Citations - 11998
Francesco Scaravilli is an academic researcher from University College London. The author has contributed to research in topics: Epilepsy & Neuropathology. The author has an hindex of 51, co-authored 156 publications receiving 11437 citations.
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Journal ArticleDOI
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.
Brinda Ravikumar,Coralie Vacher,Zdenek Berger,Janet E. Davies,Shouqing Luo,Lourdes Garcia Oroz,Francesco Scaravilli,Douglas F. Easton,Rainer Duden,Cahir J. O'Kane,David C. Rubinsztein +10 more
TL;DR: This work shows that mammalian target of rapamycin (mTOR) is sequestered in polyglutamine aggregates in cell models, transgenic mice and human brains, and provides proof-of-principle for the potential of inducing autophagy to treat Huntington disease.
Journal ArticleDOI
Magnetization transfer ratio and myelin in postmortem multiple sclerosis brain
Klaus Schmierer,Francesco Scaravilli,Daniel R. Altmann,Daniel R. Altmann,Gareth J. Barker,Gareth J. Barker,David Miller +6 more
TL;DR: MTR is affected by myelin content in MS white matter, and the extent of gliosis was detected using morphometric and digital imaging techniques.
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The role of NMR imaging in the assessment of multiple sclerosis and isolated neurological lesions. A quantitative study.
I. E. C. Ormerod,David Miller,W. I. McDonald,E. P. G. H. Du Boulay,Peter Rudge,B. E. Kendall,I. F. Moseley,Glyn Johnson,Ps Tofts,A.M. Halliday,Adolfo M. Bronstein,Francesco Scaravilli,A. E. Harding,D. Barnes,K. J. Zilkha +14 more
TL;DR: Evidence is adduced to support the view that an important source of the abnormal NMR signals in acute lesions is oedema, and in chronic lesions is gliosis; demyelination per se is unlikely to make an important contribution.
Journal ArticleDOI
Diffusion tensor imaging of post mortem multiple sclerosis brain
Klaus Schmierer,Claudia A. M. Wheeler-Kingshott,P A Boulby,Francesco Scaravilli,Daniel R. Altmann,Gareth J. Barker,Paul S. Tofts,David Miller +7 more
TL;DR: It is suggested that FA and MD are affected by myelin content and – to a lesser degree – axonal count in post mortem MS brain.
Journal ArticleDOI
HIV-associated disease of the nervous system: review of nomenclature and proposal for neuropathology-based terminology.
Herbert Budka,Clayton A. Wiley,Paul Kleihues,Juan Artigas,Arthur K. Asbury,Eun Sook Cho,David R. Cornblath,Mauro C. Dal Canto,Umberto DeGirolami,Dennis W. Dickson,Leon G. Epstein,Margaret M. Esiri,Felice Giangaspero,Georg Gosztonyi,Françoise Gray,John W. Griffin,Dominique Hénin,Yuzo Iwasaki,Robert S. Janssen,Richard T. Johnson,Peter L. Lantos,William D. Lyman,Justin C. McArthur,Kazuo Nagashima,Nancy S. Peress,Carol K. Petito,Richard W. Price,Roy H. Rhodes,Marc K. Rosenblum,Gérard Said,Francesco Scaravilli,Leroy R. Sharer,Harry V. Vinters +32 more
TL;DR: Herbert Budka 1, Clayton A. Wiley 2, Paul Kleihues 3, Juan Artigas 4, Arthur K. Asbury 5, Eun-Sook Cho 6, David R. Cornblath 7, Mauro C. Dal Canto 8, Umberto DeGirolami 9, Dennis Dickson 10, Leon G. Epstein 11, Margaret M. Esiri 12, Felice Giangaspero 13, Georg Gosztonyi 14,