C
Cai Zhang
Researcher at Cincinnati Children's Hospital Medical Center
Publications - 4
Citations - 85
Cai Zhang is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: microRNA & RNA interference. The author has an hindex of 2, co-authored 4 publications receiving 73 citations. Previous affiliations of Cai Zhang include Huazhong University of Science and Technology.
Papers
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Journal ArticleDOI
A critical role for PKR complexes with TRBP in Immunometabolic regulation and eIF2α phosphorylation in obesity.
Takahisa Nakamura,Takahisa Nakamura,Ryan C. Kunz,Cai Zhang,Taishi Kimura,Celvie L. Yuan,Brenna Baccaro,Yuka Namiki,Steven P. Gygi,Gökhan S. Hotamisligil +9 more
TL;DR: It is shown that TRBP phosphorylation is induced in the setting of metabolic stress, leading to PKR activation, which indicates that the association between PKR and TRBP integrates metabolism with translational control and inflammatory signaling and plays important roles in metabolic homeostasis and disease.
Journal ArticleDOI
Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology.
Cai Zhang,Cai Zhang,Joonbae Seo,Kazutoshi Murakami,Esam S. B. Salem,Esam S. B. Salem,Elise Bernhard,Vishnupriya J. Borra,Kwangmin Choi,Celvie L. Yuan,Calvin C. Chan,Xiaoting Chen,Taosheng Huang,Taosheng Huang,Matthew T. Weirauch,Matthew T. Weirauch,Senad Divanovic,Senad Divanovic,Nathan Qi,Hala Einakat Thomas,Carol A. Mercer,Haruhiko Siomi,Takahisa Nakamura,Takahisa Nakamura +23 more
TL;DR: The authors show that RISC component Argonaute 2 in the liver regulates energy metabolism by inducing microRNAs that cause metabolic disruption and by suppressing protein translation linked to AMPK activation.
Journal ArticleDOI
Hepatic Ago2 Regulates PPARα for Oxidative Metabolism Linked to Glycemic Control in Obesity and Post Bariatric Surgery.
Jashdeep Bhattacharjee,Vishnupriya J. Borra,Esam S. B. Salem,Esam S. B. Salem,Cai Zhang,Kazutoshi Murakami,Rupinder K. Gill,Ahlee Kim,James K. Kim,Rosa Maria Salazar-Gonzalez,Mikako Warren,Rohit Kohli,Takahisa Nakamura +12 more
TL;DR: In this paper, the authors showed that hepatic Ago2-deficiency in mice (L-Ago2 knockout [KO] mice) enhances mitochondrial oxidation and alleviates obesity-associated pathophysiology.
Book ChapterDOI
Cellular Approaches in Investigating Argonaute2-Dependent RNA Silencing.
TL;DR: The methods for establishing Ago2-deficient MEFs and for reconstituting the MEFs with an Ago2 mutant lacking its slicer activity by means of a retrovirus-mediated gene transfer are described.