T
Takahisa Nakamura
Researcher at Cincinnati Children's Hospital Medical Center
Publications - 56
Citations - 5397
Takahisa Nakamura is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Protein kinase R & Hypernova. The author has an hindex of 26, co-authored 54 publications receiving 4918 citations. Previous affiliations of Takahisa Nakamura include National Institute for Basic Biology, Japan & Tohoku University.
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Journal ArticleDOI
An Unusual Supernova in the Error Box of the Gamma-Ray Burst of 25 April 1998
Titus Galama,P. M. Vreeswijk,J. van Paradijs,J. van Paradijs,Chryssa Kouveliotou,Chryssa Kouveliotou,T. Augusteijn,H. Böhnhardt,J. Brewer,V. Doublier,J.-F. Gonzalez,Bruno Leibundgut,C. Lidman,Olivier Hainaut,Ferdinando Patat,John Heise,J. J. M. in 't Zand,Kevin Hurley,Paul J. Groot,Richard G. Strom,Paolo A. Mazzali,Koichi Iwamoto,Ken'ichi Nomoto,Hideyuki Umeda,Takahisa Nakamura,T. R. Young,Tsutomu Suzuki,Toshikazu Shigeyama,Thomas M. Koshut,Marc Kippen,Marc Kippen,C. R. Robinson,C. R. Robinson,P. de Wildt,Ralph A. M. J. Wijers,Nial R. Tanvir,Jochen Greiner,Elena Pian,E. Palazzi,F. Frontera,N. Masetti,Luciano Nicastro,M. Feroci,Enrico Costa,L. Piro,Bruce A. Peterson,C. G. Tinney,B. J. Boyle,Russell D. Cannon,R. A. Stathakis,Elaine M. Sadler,Michael C. Begam,Philip A. Ianna +52 more
TL;DR: In this paper, the authors reported the discovery of transient optical emission in the error box of the gamma-ray burst GRB980425, the light curve of which was very different from that of previous optical afterglows associated with Gamma-ray bursts.
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Novel role of PKR in inflammasome activation and HMGB1 release
Ben Lu,Takahisa Nakamura,Karen Inouye,Jianhua Li,Yiting Tang,Peter Lundbäck,Sergio I. Valdés-Ferrer,Peder S. Olofsson,Thomas Kalb,Jesse Roth,Yongrui Zou,Helena Erlandsson-Harris,Huan Yang,Jenny P.-Y. Ting,Haichao Wang,Ulf Andersson,Daniel J. Antoine,Sangeeta S. Chavan,Gökhan S. Hotamisligil,Kevin J. Tracey +19 more
TL;DR: Results show a crucial role for PKR in inflammasome activation, and indicate that it should be possible to pharmacologically target this molecule to treat inflammation.
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A hypernova model for the supernova associated with the gamma ray burst of 25 April 1998
Koichi Iwamoto,Paolo A. Mazzali,Ken'ichi Nomoto,Hideyuki Umeda,Takahisa Nakamura,Ferdinando Patat,I. J. Danziger,T. R. Young,Tsutomu Suzuki,Toshikazu Shigeyama,T. Augusteijn,V. Doublier,J.-F. Gonzalez,H. Boehnhardt,J. Brewer,Olivier Hainaut,Christopher Lidman,Bruno Leibundgut,Enrico Cappellaro,Massimo Turatto,Titus Galama,P. M. Vreeswijk,Chryssa Kouveliotou,J. van Paradijs,J. van Paradijs,Elena Pian,E. Palazzi,Filippo Frontera +27 more
TL;DR: The discovery of the unusual supernova SN1998bw, and its possible association with the γ-ray burst GRB 9804251,2,3, provide new insights into the explosion mechanism of very massive stars and the origin of some classes of gamma-ray bursts.
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Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis
Takahisa Nakamura,Masato Furuhashi,Ping Li,Haiming Cao,Gurol Tuncman,Nahum Sonenberg,Cem Z. Görgün,Gökhan S. Hotamisligil,Gökhan S. Hotamisligil +8 more
TL;DR: Evidence is provided that double-stranded RNA-dependent protein kinase (PKR) can respond to nutrient signals as well as endoplasmic reticulum (ER) stress and coordinate the activity of other critical inflammatory kinases to regulate insulin action and metabolism.
Journal ArticleDOI
Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation
TL;DR: Tob inhibits cell growth by suppressing cyclin D1 expression, which is canceled by Erk1- and Erk2-mediated Tob phosphorylation, and it is proposed that Tob is critically involved in the control of early G(1) progression.