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Celvie L. Yuan
Researcher at Cincinnati Children's Hospital Medical Center
Publications - 17
Citations - 3753
Celvie L. Yuan is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Translation (biology) & Unfolded protein response. The author has an hindex of 16, co-authored 17 publications receiving 2508 citations. Previous affiliations of Celvie L. Yuan include Case Western Reserve University.
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Journal ArticleDOI
Recognition of RNA N 6 -methyladenosine by IGF2BP proteins enhances mRNA stability and translation
Huilin Huang,Huilin Huang,Hengyou Weng,Hengyou Weng,Wen-Ju Sun,Xi Qin,Xi Qin,Hailing Shi,Hailing Shi,Huizhe Wu,Huizhe Wu,Huizhe Wu,Boxuan Simen Zhao,Boxuan Simen Zhao,Ana Mesquita,Chang Liu,Chang Liu,Celvie L. Yuan,Yueh-Chiang Hu,Stefan Hüttelmaier,Jennifer R. Skibbe,Rui Su,Rui Su,Xiaolan Deng,Xiaolan Deng,Xiaolan Deng,Lei Dong,Lei Dong,Miao Sun,Chenying Li,Chenying Li,Chenying Li,Sigrid Nachtergaele,Sigrid Nachtergaele,Yungui Wang,Yungui Wang,Chao Hu,Chao Hu,Kyle Ferchen,Kenneth D. Greis,Xi Jiang,Xi Jiang,Minjie Wei,Liang-Hu Qu,Jun-Lin Guan,Chuan He,Chuan He,Jian-Hua Yang,Jianjun Chen,Jianjun Chen +49 more
TL;DR: This work reports the insulin-like growth factor 2 mRNA-binding proteins as a distinct family of m6A readers that target thousands of mRNA transcripts through recognizing the consensus GG(m6A)C sequence, and identifies IGF2BPs as an additional class of N6-methyladenosine (m 6A) reader proteins.
Journal ArticleDOI
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death
Jaeseok Han,Sung Hoon Back,Junguk Hur,Yu Hsuan Lin,Robert D. Gildersleeve,Jixiu Shan,Celvie L. Yuan,Dawid Krokowski,Shiyu Wang,Maria Hatzoglou,Michael S. Kilberg,Maureen A. Sartor,Randal J. Kaufman +12 more
TL;DR: It is shown that eIF2α-phosphorylation-attenuated protein synthesis, and not Atf4 mRNA translation, promotes cell survival, and suggesting that limiting protein synthesis will be therapeutic for diseases caused by protein misfolding in the ER.
Journal ArticleDOI
Histone H3 trimethylation at lysine 36 guides m 6 A RNA modification co-transcriptionally
Huilin Huang,Huilin Huang,Hengyou Weng,Hengyou Weng,Ke-Ren Zhou,Tong Wu,Boxuan Simen Zhao,Mingli Sun,Mingli Sun,Zhenhua Chen,Xiaolan Deng,Xiaolan Deng,Xiaolan Deng,Gang Xiao,Franziska Auer,Lars Klemm,Huizhe Wu,Huizhe Wu,Huizhe Wu,Zhixiang Zuo,Zhixiang Zuo,Xi Qin,Xi Qin,Yunzhu Dong,Yile Zhou,Hanjun Qin,Shu Tao,Juan Du,Jun Liu,Zhike Lu,Hang Yin,Ana Mesquita,Celvie L. Yuan,Yueh-Chiang Hu,Wen-Ju Sun,Rui Su,Rui Su,Lei Dong,Lei Dong,Chao Shen,Chao Shen,Chenying Li,Chenying Li,Ying Qing,Ying Qing,Xi Jiang,Xiwei Wu,Miao Sun,Miao Sun,Jun-Lin Guan,Liang-Hu Qu,Minjie Wei,Markus Müschen,Gang Huang,Chuan He,Jian-Hua Yang,Jianjun Chen,Jianjun Chen +57 more
TL;DR: It is reported that histone H3 trimethylation at Lys36 (H3K36me3), a marker for transcription elongation, guides m6A deposition globally, and it is shown that m 6A modifications are enriched in the vicinity of H3K 36me3 peaks, and are reduced globally when cellular H 3K36 me3 is depleted.
Journal ArticleDOI
A Self-defeating Anabolic Program Leads to β-Cell Apoptosis in Endoplasmic Reticulum Stress-induced Diabetes via Regulation of Amino Acid Flux
Dawid Krokowski,Jaeseok Han,Mridusmita Saikia,Mithu Majumder,Celvie L. Yuan,Bo-Jhih Guan,Elena Bevilacqua,Ovidio Bussolati,Stefan Bröer,Peter Arvan,Marek Tchórzewski,Martin D. Snider,Michelle Puchowicz,Colleen M. Croniger,Scot R. Kimball,Tao Pan,Antonis E. Koromilas,Randal J. Kaufman,Maria Hatzoglou +18 more
TL;DR: It is reported here that chronic ER stress correlated with increased islet protein synthesis and apoptosis in β-cells in vivo, and the increased expression of amino acid transporters in islets can serve as early diagnostic biomarkers for the development of diabetes.
Journal ArticleDOI
Molecular Symbiosis of CHOP and C/EBPβ Isoform LIP Contributes to Endoplasmic Reticulum Stress-Induced Apoptosis
TL;DR: It is shown that the bZIP protein C/EBPβ isoform LIP is required for nuclear translocation of CHOP during ER stress and the LIP-CHOP interaction has a stabilizing role for LIP, and this functional cooperativity as molecular symbiosis between proteins is proposed.