Nai-Ying Zheng

TL;DR: Although scarce after annual influenza vaccination, B cells producing antibodies capable of neutralizing multiple influenza strains are abundant in humans infected with pandemic 2009 H1N1 influenza.

TL;DR: Antibiotics treatment prior and subsequent to seasonal influenza vaccination revealed significant associations between bacterial species and metabolic phenotypes, highlighting a key role for the microbiome in modulating human immunity.

TL;DR: The broadly cross-reactive non-neutralizing antibodies generated in this study were protective through Fc-mediated effector cell recruitment and provide a better understanding of the human monoclonal antibody response to influenza in the context of vaccines.

TL;DR: This is the first identification of a distinct mature human B cell subset that is naturally autoreactive and controlled by the tolerizing mechanism of functional anergy.

TL;DR: It is shown that recent H1N1 strains possess a mutation that allows viruses to avoid immune responses elicited in middle-aged adults, and it is suggested that new viral strains should be incorporated into seasonal influenza vaccines so that proper immunity is eliciting in all humans, regardless of age and pre-exposure histories.