Top 14 papers published by Caixia Gao from Chinese Academy of Sciences in 2023

TL;DR: In this paper , the authors discuss advances of various principles and technologies in the mainstream of the enabling technology of synthetic biology, including synthesis and assembly of a genome, DNA storage, gene editing, molecular evolution and de novo design of function proteins, cell and gene circuit engineering, cell-free synthetic biology and artificial intelligence-aided synthetic biology.

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Abstract: Synthetic biology provides a new paradigm for life science research (“build to learn”) and opens the future journey of biotechnology (“build to use”). Here, we discuss advances of various principles and technologies in the mainstream of the enabling technology of synthetic biology, including synthesis and assembly of a genome, DNA storage, gene editing, molecular evolution and de novo design of function proteins, cell and gene circuit engineering, cell-free synthetic biology, artificial intelligence (AI)-aided synthetic biology, as well as biofoundries. We also introduce the concept of quantitative synthetic biology, which is guiding synthetic biology towards increased accuracy and predictability or the real rational design. We conclude that synthetic biology will establish its disciplinary system with the iterative development of enabling technologies and the maturity of the core theory.

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2 citations

Posted Content•DOI•

Discovery of deaminase functions by structure-based protein clustering

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Qiupeng Lin, Hongyuan Fei, Zi-Jian He, Hu Xu, Yunjia Li, Kunli Qu, Peng Han, Qiang Gao, Boshu Li, Guanwen Liu, Lixiao Zhang, Jiacheng Hu, Rui Zhang, Erwei Zuo, Yonglun Luo, Yidong Ran, Jin-Long Qiu, Kevin T. Zhao, Caixia Gao - Show less +15 more

22 May 2023-Cell

TL;DR: The authors used AlphaFold2 to predict and subsequently cluster an entire protein family based on predicted structure similarities, and applied these new deaminases to the development of new cytosine base editors with distinct features.

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1 citations

Journal Article•DOI•

A physical method for downscaling land surface temperatures using surface energy balance theory

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Yong Hu, Ronglin Tang, Zhao-Liang Li, Yazhen Jiang, Meng Liu, Caixia Gao, Xiaoming Zhou - Show less +3 more

01 Mar 2023-Remote Sensing of Environment

TL;DR: In this article , a physical surface energy balance (SEB)-based LST downscaling method (DTsEB) is developed to downscale coarse remotely sensed thermal infrared LST products with fine-resolution visible and near-infrared data.

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1 citations

Journal Article•DOI•

Field dissemination of the value of the quantity method of the spectroradiometer in visible-to-shortwave infrared

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Qiu-tong Cheng, Ling Li, C. Dai, Caixia Gao, Yanfei Wang - Show less +1 more

01 Jan 2023-Journal of remote sensing

TL;DR: In this paper , the authors proposed a method to improve the quality of the data collected by the data collection system. But they did not specify how to collect the data from the data.

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Journal Article•DOI•

On-orbit absolute radiometric calibration for optical remote sensing satellites： Progress and trends

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Lingling Ma, Ning Wang, Caixia Gao, Yongguang Zhao, Benyong Yang, Xinhong Wang, Qijin Han, Na Xu, Yaokai Liu - Show less +5 more

01 Jan 2023-Journal of remote sensing

TL;DR: In this paper , the authors describe the relationship between the authors and the authors of this article: "The authors of the article stated that the authors were motivated by the following reasons:

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Journal Article•DOI•

Time-series absolute radiometric calibration and trend analysis of the wide swath sensor onboard GF-6 satellite with automatic radiometric calibration site

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Yaokai Liu, Lingling Ma, Renfei Wang, Qingchuan Zheng, Wan Li, Yongguang Zhao, Ning Wang, Caixia Gao, Xiaoxin Hou - Show less +5 more

01 Jan 2023-Journal of remote sensing

TL;DR: In this article , the authors propose a method to improve the quality of the data collected by the data collection system, which is based on the concept of data augmentation, and use it to increase the efficiency of data collection.

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Journal Article•DOI•

Discovery of deaminase functions by structure-based protein clustering

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Kevin T. Zhao¹, Caixia Gao²•Institutions (2)

Harvard University¹, University of Chinese Academy of Sciences²

01 Jun 2023-Cell

TL;DR: This article used AlphaFold2 to predict and subsequently cluster an entire protein family based on predicted structure similarities, and found that most proteins in the DddA-like clade were not double-stranded DNA deaminases.

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Journal Article•DOI•

A Physical-Based Method for Pixel-by-Pixel Quantifying Uncertainty of Land Surface Temperature Retrieval From Satellite Thermal Infrared Data Using the Generalized Split-Window Algorithm

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Yang Gui, Si-Bo Duan, Zhao-Liang Li, Cheng Huang, Meng Liu, Xiangyang Liu, Caixia Gao - Show less +3 more

IEEE Transactions on Geoscience and Remote Sensing

TL;DR: In this article , a physical-based method was proposed to quantify the uncertainty of LST retrieval from satellite thermal infrared (TIR) data using the generalized split-window (GSW) algorithm.

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Abstract: Land surface temperature (LST) is an important physical parameter at the interface between the Earth’s surface and the atmosphere. Accurately quantifying LST uncertainty is essential for the generation of a long-term and consistent LST Climate Data Record (CDR) or Earth System Data Record (ESDR) from either multiple sensors or algorithms. In this study, a physical-based method was proposed to quantify the uncertainty of LST retrieval from satellite thermal infrared (TIR) data using the generalized split-window (GSW) algorithm. LST uncertainties were parameterized as a function of brightness temperature at the top of the atmosphere (TOA) and surface emissivity in two split-window channels, which are two key input parameters in the GSW algorithm, as well as their uncertainties. The performance of the parameterized uncertainty model was evaluated according to the simulation dataset at six prescribed viewing zenith angles (VZAs) of 0°, 33.56°, 44.42°, 51.32°, 56.25°, and 60°, with a root mean squared error (RMSE) of 0.001 K. The coefficients of the parameterized uncertainty model at arbitrary VZA within a sensor’s field of view (FOV) can be obtained by linear interpolation of the coefficients at the six prescribed VZAs. Once the coefficients of the parameterized uncertainty model for each pixel are available, total LST uncertainties can be quantified on a pixel-by-pixel basis. As an example, the parameterized uncertainty model was applied to actual MODIS data for displaying the spatial distribution of LST uncertainties. The results indicate that the parameterized uncertainty model can characterize the spatial variation in LST uncertainties well over various land cover types.

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Posted Content•DOI•

Epigenetic modifications mediate cultivar-specific root development and metabolic adaptation to nitrogen availability in wheat

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Hao Zhang, Fa Cui, Long Zhao, Xiaoyu Zhang, Jinchao Chen, Jing Zhang, Yongpeng Li, YanXiao Niu, Liang Wang, Caixia Gao, Xiang-Dong Fu, Yiping Tong, Hong-Qing Ling, Junming Li, Jun Xiao - Show less +11 more

26 Feb 2023-bioRxiv

TL;DR: In this article , the role of epigenetic modification in the regulation of cultivar-specific responses to low nitrogen (LN) constraint is not well understood, and the chromatin landscapes in roots, leaves, and seeds in two wheat cultivars (KN9204 and J411) were analyzed.

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Abstract: The breeding of crops with improved nitrogen use efficiency (NUE) is crucial for sustainable agriculture. However, the role of epigenetic modification in the regulation of cultivar-specific responses to low nitrogen (LN) constraint is not well understood. Here, we analyzed the chromatin landscapes in roots, leaves, and seeds in two wheat cultivars (KN9204 and J411) that differ radically in NUE under normal and nitrogen-limited conditions. Transcriptional regulatory chromatin regions exhibited a clear cultivar-specificity between KN9204 and J411. Cultivar-specific regulation of nitrogen metabolism genes (NMGs) is linked to variation in histone modification levels, rather than differences in DNA sequence. Cultivar-specific histone modification regions were found to contribute to the genetic regulation of NUE-related traits, such as QTL locus of maximum root length of qMRL-7B. Furthermore, LN-induced H3K27ac and H3K27me3 dynamics enhanced root growth more in KN9204, while strengthened the nitrogen uptake system more in J411. Evidence from histone deacetylase inhibitor treatment and transgenic plants with loss-of-function of the H3K27me3 methyltransferase further showed that changes in epigenetic modifications can alter the strategy for root development and nitrogen uptake in response to LN constraint. Taken together, the results of our study highlight the importance of epigenetic regulation in mediating cultivar-specific root development and metabolic adaptation to LN in wheat.

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Journal Article•DOI•

The near-space altitude experiment for satellite radiometric calibration and the first results

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Ning Wang, Lingling Ma, Qiang Liu, Yongguang Zhao, Geer Teng, Yaokai Liu, Caixia Gao, Donghui Zhang, Jingmei Li, Renfei Wang, Beibei Zhang, Hailiang Gao, Qijin Han, Yanchu Yang, Qingchuan Zheng, Guangzhou Ouyang - Show less +12 more

01 Jan 2023-Journal of remote sensing

TL;DR: In this paper , the authors discuss the effect of gender discrimination on women's reproductive health and gender equality in the context of women's sexual health, and propose a strategy to improve women's health.

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Journal Article•DOI•

Analysis of the thermal infrared radiation characteristics of a typical land surface stable target and applicability assessments

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Zhiwei Yang, Caixia Gao, Shi Qiu, Lingling Ma, Yonggang Qian, Yongguang Zhao - Show less +2 more

01 Jan 2023-Journal of remote sensing

TL;DR: Aqua/MODIS as mentioned in this paper ) is another example of a system that uses a set of parameters to determine whether a user should be allowed to leave the house or not, based on which he or she should leave.

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Showing papers by "Caixia Gao published in 2023"