C
Carine Ciron
Researcher at Institut national de la recherche agronomique
Publications - 14
Citations - 530
Carine Ciron is an academic researcher from Institut national de la recherche agronomique. The author has contributed to research in topics: Antibody & Medicine. The author has an hindex of 8, co-authored 9 publications receiving 449 citations. Previous affiliations of Carine Ciron include École Normale Supérieure & University of Nantes.
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Journal ArticleDOI
Safe, efficient, and reproducible gene therapy of the brain in the dog models of Sanfilippo and Hurler syndromes.
N. Matthew Ellinwood,Jérôme Ausseil,Jérôme Ausseil,Nathalie Desmaris,Nathalie Desmaris,Stéphanie Bigou,Stéphanie Bigou,Song Liu,Song Liu,Jackie K. Jens,Elizabeth M. Snella,Eman E.A. Mohammed,Christopher B. Thomson,Sylvie Raoul,Béatrice Joussemet,Françoise A. Roux,Yan Cherel,Yaouen Lajat,Monique Piraud,Rachid Benchaouir,Stephan Hermening,Harald Petry,Roseline Froissart,Marc Tardieu,Carine Ciron,Philippe Moullier,Jennifer D. Parkes,Karen L. Kline,Irène Maire,Marie-Thérèse Vanier,Jean-Michel Heard,Jean-Michel Heard,Marie-Anne Colle +32 more
TL;DR: In immunosuppressed dogs, vector was efficiently delivered throughout the brain, induced α-N-acetyl-glucosaminidase production, cleared stored compounds and storage lesions, and strongly support projects of human trials aimed at assessing this treatment in Sanfilippo syndrome.
Journal ArticleDOI
Gene therapy of the brain in the dog model of Hurler's syndrome.
Carine Ciron,Nathalie Desmaris,Marie-Anne Colle,Sylvie Raoul,Béatrice Joussemet,Lucie Verot,Jérôme Ausseil,Roseline Froissart,Françoise A. Roux,Yan Cherel,Nicolas Ferry,Yaouen Lajat,Bertrand Schwartz,Marie-Thérèse Vanier,Irène Maire,Marc Tardieu,Philippe Moullier,Jean-Michel Heard,Jean-Michel Heard +18 more
TL;DR: Delivery of the missing enzyme through stereotactic injection of adeno‐associated virus vectors coding for IDUA prevents neuropathology in affected mice and in enzyme‐deficient dogs.
Journal ArticleDOI
Evidence for encapsidation of prokaryotic sequences during recombinant adeno-associated virus production and their in vivo persistence after vector delivery.
TL;DR: The need for more stringent characterization of rAAV stocks is highlighted and useful information is provided on the development of r AAV production methods that are able to circumvent or limit the generation of such undesirable particles.
Journal ArticleDOI
Human α-Iduronidase Gene Transfer Mediated by Adeno-Associated Virus Types 1, 2, and 5 in the Brain of Nonhuman Primates: Vector Diffusion and Biodistribution
Carine Ciron,Arnaud Cressant,Françoise A. Roux,Sylvie Raoul,Yan Cherel,Philippe Hantraye,Nicole Déglon,Bertrand Schwartz,Martine Barkats,Jean-Michel Heard,Marc Tardieu,Philippe Moullier,Marie-Anne Colle +12 more
TL;DR: It was found that global diffusion throughout the brain was not significantly different between the three serotypes, but rAAV2/1 and rAAVs2/5 resulted in higher vector copy numbers per cell than did rAAv2/2, respectively, in the brain and the distal neuronal structures (spinal cord and peripheral nerves).
Journal ArticleDOI
Efficient CNS targeting in adult mice by intrathecal infusion of single-stranded AAV9-GFP for gene therapy of neurological disorders.
Karim Bey,Carine Ciron,Laurence Dubreil,Johan Deniaud,Mireille Ledevin,J Cristini,Véronique Blouin,Patrick Aubourg,Marie-Anne Colle +8 more
TL;DR: It-Lumb ssAAV9 delivery is a safe and highly efficient means of targeting the CNS in adult mice via intracisternal (iCist) or intralumbar (it-LUM) administration.