M
Marie-Anne Colle
Researcher at Institut national de la recherche agronomique
Publications - 37
Citations - 1358
Marie-Anne Colle is an academic researcher from Institut national de la recherche agronomique. The author has contributed to research in topics: Metachromatic leukodystrophy & Lysosomal storage disease. The author has an hindex of 18, co-authored 35 publications receiving 1181 citations. Previous affiliations of Marie-Anne Colle include University of Nantes & École Normale Supérieure.
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Journal ArticleDOI
Multiple Immune Factors Are Involved in Controlling Acute and Chronic Chikungunya Virus Infection
Yee Suan Poo,Penny A. Rudd,Joy Gardner,Jane A. C. Wilson,Thibaut Larcher,Marie-Anne Colle,Thuy T. Le,Helder I. Nakaya,David Warrilow,Richard J.N. Allcock,Helle Bielefeldt-Ohmann,Wayne A. Schroder,Alexander A. Khromykh,José A. López,Andreas Suhrbier +14 more
TL;DR: It is suggested that chronic arthritic disease is a consequence of persistent, replicating and transcriptionally active CHIKV RNA, and several factors are involved in virus control.
Journal ArticleDOI
Safe, efficient, and reproducible gene therapy of the brain in the dog models of Sanfilippo and Hurler syndromes.
N. Matthew Ellinwood,Jérôme Ausseil,Jérôme Ausseil,Nathalie Desmaris,Nathalie Desmaris,Stéphanie Bigou,Stéphanie Bigou,Song Liu,Song Liu,Jackie K. Jens,Elizabeth M. Snella,Eman E.A. Mohammed,Christopher B. Thomson,Sylvie Raoul,Béatrice Joussemet,Françoise A. Roux,Yan Cherel,Yaouen Lajat,Monique Piraud,Rachid Benchaouir,Stephan Hermening,Harald Petry,Roseline Froissart,Marc Tardieu,Carine Ciron,Philippe Moullier,Jennifer D. Parkes,Karen L. Kline,Irène Maire,Marie-Thérèse Vanier,Jean-Michel Heard,Jean-Michel Heard,Marie-Anne Colle +32 more
TL;DR: In immunosuppressed dogs, vector was efficiently delivered throughout the brain, induced α-N-acetyl-glucosaminidase production, cleared stored compounds and storage lesions, and strongly support projects of human trials aimed at assessing this treatment in Sanfilippo syndrome.
Journal ArticleDOI
Gene therapy of the brain in the dog model of Hurler's syndrome.
Carine Ciron,Nathalie Desmaris,Marie-Anne Colle,Sylvie Raoul,Béatrice Joussemet,Lucie Verot,Jérôme Ausseil,Roseline Froissart,Françoise A. Roux,Yan Cherel,Nicolas Ferry,Yaouen Lajat,Bertrand Schwartz,Marie-Thérèse Vanier,Irène Maire,Marc Tardieu,Philippe Moullier,Jean-Michel Heard,Jean-Michel Heard +18 more
TL;DR: Delivery of the missing enzyme through stereotactic injection of adeno‐associated virus vectors coding for IDUA prevents neuropathology in affected mice and in enzyme‐deficient dogs.
Journal ArticleDOI
Biodistribution of rAAV Vectors Following Intraocular Administration: Evidence for the Presence and Persistence of Vector DNA in the Optic Nerve and in the Brain
Nathalie Provost,Guylène Le Meur,Michel Weber,Alexandra Mendes-Madeira,Guillaume Podevin,Yan Cherel,Marie-Anne Colle,Jack-Yves Deschamps,Philippe Moullier,Fabienne Rolling +9 more
TL;DR: The most striking finding was the detection of vector sequences in the brain, along the visual pathway, in rAAV-2/2 intravitreally injected dogs, which raises safety concerns regarding intraocular administration of rAAVs and will have an impact on the development of future gene therapy trials for retinal diseases.
Journal ArticleDOI
Subretinal delivery of recombinant AAV serotype 8 vector in dogs results in gene transfer to neurons in the brain.
Knut Stieger,Marie-Anne Colle,Laurence Dubreil,Alexandra Mendes-Madeira,Michel Weber,Guylène Le Meur,Jack-Yves Deschamps,Nathalie Provost,D. Nivard,Yan Cherel,Philippe Moullier,Fabienne Rolling +11 more
TL;DR: Recombinant adeno-associated virus (rAAV) vectors are among the most efficient gene delivery vehicles for gene transfer to the retina and, surprisingly, in dogs, gene transfer also occurred distal to the injection site in neurons of the lateral geniculate nucleus of the brain.