C
Carl Jorns
Researcher at Karolinska University Hospital
Publications - 50
Citations - 1061
Carl Jorns is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Transplantation & Hepatocyte. The author has an hindex of 14, co-authored 42 publications receiving 839 citations. Previous affiliations of Carl Jorns include University of South Florida St. Petersburg & Karolinska Institutet.
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Journal ArticleDOI
Induction of MxA Gene Expression by Influenza A Virus Requires Type I or Type III Interferon Signaling
Dirk Holzinger,Carl Jorns,Silke Stertz,Stéphanie Boisson-Dupuis,Robert Thimme,Manfred Weidmann,Jean-Laurent Casanova,Otto Haller,Georg Kochs +8 more
TL;DR: MxA is a unique marker for the detection of type I and type III IFN activity during virus infections and IFN therapy, and cannot be triggered directly by virus infection.
Journal ArticleDOI
Hepatocyte transplantation for inherited metabolic diseases of the liver.
Carl Jorns,Ewa Ellis,Greg Nowak,Björn Fischler,Antal Nemeth,Stephen C. Strom,Bo-Göran Ericzon +6 more
TL;DR: The experience of hepatocytes transplantation for metabolic liver diseases is reviewed and the major obstacles that need to be overcome are discussed to establish hepatocyte transplantation as a reliable treatment option in the clinic.
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Elevated Numbers of FcγRIIIA+ (CD16+) Effector CD8 T Cells with NK Cell-Like Function in Chronic Hepatitis C Virus Infection
Niklas K. Björkström,Veronica D. Gonzalez,Karl-Johan Malmberg,Karolin Falconer,Annette Alaeus,Greg Nowak,Carl Jorns,Bo-Göran Ericzon,Ola Weiland,Johan K. Sandberg,Hans-Gustaf Ljunggren +10 more
TL;DR: It is suggested that CD8 T cells, during chronic HCV infection in humans, continue to differentiate beyond defined stages of terminal effector cells, acquiring CD16 and NK cell-like functional properties.
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Composition and functionality of the intrahepatic innate lymphoid cell-compartment in human nonfibrotic and fibrotic livers.
Marianne Forkel,Lena Berglin,Eliisa Kekäläinen,Adrian Carlsson,Emma Svedin,Jakob Michaëlsson,Maho Nagasawa,Jonas S. Erjefält,Michiko Mori,Malin Flodström-Tullberg,Annika Bergquist,Hans-Gustaf Ljunggren,Magnus Westgren,Ulrik Lindforss,Danielle Friberg,Carl Jorns,Ewa Ellis,Niklas K. Björkström,Jenny Mjösberg,Jenny Mjösberg +19 more
TL;DR: The results indicate a role for I LC2s in human liver fibrosis, implying that targeting ILC2s might be a novel therapeutic strategy for its treatment, and provide the first detailed characterization of intrahepatic ILCs inhuman adult and fetal liver.
Journal ArticleDOI
De Novo Donor-Specific HLA Antibody Formation in Two Patients With Crigler-Najjar Syndrome Type I Following Human Hepatocyte Transplantation With Partial Hepatectomy Preconditioning
Carl Jorns,Greg Nowak,Antal Nemeth,Helen Zemack,L-M Mörk,Helena Johansson,Roberto Gramignoli,M Watanabe,Ahmad Karadagi,M Alheim,Dan Hauzenberger,R. van Dijk,Piter J. Bosma,Finn Ebbesen,Attila Szakos,Björn Fischler,Stephen C. Strom,Ewa Ellis,B-G Ericzon +18 more
TL;DR: This study provides the first description of de novo DSAs after hepatocyte transplantation associated with graft loss, and induced a robust release of hepatocyte growth factor, but its efficacy on hepatocyte engraftment needs to be evaluated with additional studies.