C
Carla D’Avanzo
Researcher at Harvard University
Publications - 17
Citations - 2055
Carla D’Avanzo is an academic researcher from Harvard University. The author has contributed to research in topics: Neural stem cell & Cellular differentiation. The author has an hindex of 12, co-authored 17 publications receiving 1593 citations. Previous affiliations of Carla D’Avanzo include University of California, San Diego & University of Naples Federico II.
Papers
More filters
Journal ArticleDOI
A three-dimensional human neural cell culture model of Alzheimer’s disease
Se Hoon Choi,Young Hye Kim,Matthias Hebisch,Christopher Sliwinski,Seungkyu Lee,Carla D’Avanzo,Hechao Chen,Basavaraj Hooli,Caroline Asselin,Julien Muffat,Justin Klee,Can-wen Zhang,Brian J. Wainger,Michael Peitz,Dora M. Kovacs,Clifford J. Woolf,Steven L. Wagner,Rudolph E. Tanzi,Doo Yeon Kim +18 more
TL;DR: This work reports that FAD mutations in β-amyloid precursor protein and presenilin 1 are able to induce robust extracellular deposition of amyloid-β, including amyloids-β plaques, in a human neural stem-cell-derived three-dimensional (3D) culture system, and successfully recapitulated Alzheimer’s disease pathology in a single 3D human neural cell culture system.
Journal ArticleDOI
A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer's disease.
Joseph Park,Isaac Wetzel,Ian Marriott,Didier Dréau,Carla D’Avanzo,Doo Yeon Kim,Rudolph E. Tanzi,Hansang Cho +7 more
TL;DR: A new three-dimensional (3D) human AD triculture model using neurons, astrocytes, and microglia in a 3D microfluidic platform is presented to facilitate the development of more precise human brain models for basic mechanistic studies in neural–glial interactions and drug discovery.
Journal ArticleDOI
A 3D human neural cell culture system for modeling Alzheimer's disease
Young Hye Kim,Se Hoon Choi,Carla D’Avanzo,Matthias Hebisch,Christopher Sliwinski,Enjana Bylykbashi,Kevin J. Washicosky,Justin Klee,Oliver Brüstle,Rudolph E. Tanzi,Doo Yeon Kim +10 more
TL;DR: Instructions are provided for the generation and analysis of 3D human neural cell cultures, including the production of genetically modified human neural progenitor cells with familial AD mutations, the differentiation of the hNPCs in a 3D matrix and the analysis of AD pathogenesis.
Journal ArticleDOI
Human Neurospheroid Arrays for In Vitro Studies of Alzheimer’s Disease
TL;DR: In proof of concept experiments, the neurospheroids array is validated as a sensitive and robust tool for screening compounds over extended time and is a valuable tool for studying complex neurodegenerative diseases and accelerating drug discovery.
Journal ArticleDOI
Silencing or knocking out the Na + /Ca 2+ exchanger-3 (NCX3) impairs oligodendrocyte differentiation
Francesca Boscia,Carla D’Avanzo,Anna Pannaccione,Agnese Secondo,Antonella Casamassa,Luigi Formisano,Natascia Guida,Lucio Annunziato +7 more
TL;DR: Findings indicate that calcium signaling mediated by NCX3 has a crucial role in oligodendrocyte maturation and myelin formation.