Carla López-Causapé

TL;DR: The population structure, epidemiology, antimicrobial resistance mechanisms and virulence of the P. aeruginosa high-risk clones are reviewed and the aspects related to their detection in the clinical microbiology laboratory and the implications for infection control and public health are discussed.

TL;DR: The analysis of the WGS mutational resistome has proven to be useful for understanding the evolutionary dynamics of classical resistance pathways and to describe new mechanisms for the majority of antipseudomonal classes, including β-lactams, aminoglycosides, fluoroquinolones, or polymixins.

TL;DR: The unique set of mutations responsible for the XDR phenotype of ST175 clone documented 7 years earlier were found to be conserved, denoting the long-term persistence of this specific XDR lineage in Spanish hospitals.

TL;DR: A deeper understanding of the underlying factors driving the success of high-risk clones, including the reported increased capacity for acquiring exogenous determinants, increased spontaneous mutation rates or higher ability to develop biofilms is required to develop global strategies to combat them.

TL;DR: It is shown for the first time that high-level aminoglycoside resistance in CF is likely driven by mutations in fusA1/fusA2, coding for elongation factor G, and the presence of classical mutational resistance mechanisms was confirmed and correlated with resistance phenotypes, and results also showed a major role of unexpected mutations.