Carlos Caldas

TL;DR: It is shown that the method of segmentation significantly affects the precision of the microarray data, and the histogram method gave the lowest variability across replicate spots compared to other methods, and had the lowest pixel-to-pixel variability within spots.

TL;DR: These developments are gradually leading to a change in emphasis of early clinical trials to a therapeutic model guided by the molecular classification of tumours, and functional genomic studies using RNA interference-screening tools promises to improve the classification of solid tumours by probing the relevance of each gene to tumour phenotype.

TL;DR: The present work presents a novel and scalable approaches that allow for real-time, scalable, and reproducible characterization of the H2O2 “spatially checkpoints” in the response to chemotherapy-related cancers.

TL;DR: Aurora kinase A outperforms other proliferation markers as an independent predictor of BCSS in ER-positive breast cancer and has the potential for use in routine clinical practice.

TL;DR: Data suggest that neither CBP or PCAF gene is commonly inactivated in human epithelial cancers.