C
Carlos Caldas
Researcher at University of Cambridge
Publications - 573
Citations - 86546
Carlos Caldas is an academic researcher from University of Cambridge. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 122, co-authored 547 publications receiving 73840 citations. Previous affiliations of Carlos Caldas include Institute of Cancer Research & University of Münster.
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Journal ArticleDOI
A new genome‐driven integrated classification of breast cancer and its implications
TL;DR: The characterisation of a new genome‐driven integrated classification of breast cancer is characterised, which substantially refines the existing classification systems currently used and provides a new framework for studying the underlying biology of each novel subtype.
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Allele-Specific Up-Regulation of FGFR2 Increases Susceptibility to Breast Cancer
Kerstin B. Meyer,Ana-Teresa Maia,Martin O'Reilly,Andrew E. Teschendorff,Suet-Feung Chin,Carlos Caldas,Bruce A.J. Ponder +6 more
TL;DR: A model in which the Oct-1/Runx2 and C/EBPβ binding sites in the disease-associated allele are able to lead to an increase in FGFR2 gene expression, thereby increasing the propensity for tumour formation is proposed.
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E-cadherin gene ( CDH1 ) promoter methylation as the second hit in sporadic diffuse gastric carcinoma
J. Machado,Carla Oliveira,Ralph Carvalho,Paula Soares,Geert Berx,Carlos Caldas,Raquel Seruca,Fátima Carneiro,Manuel Sobrinho-Simões +8 more
TL;DR: CDH1 promoter methylation is the second hit in more than half of the sporadic diffuse gastric carcinoma cases harboring CDH1 mutations, suggesting that tumors inactivated the remaining CDH 1 allele via a different mechanism.
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BCL2 in breast cancer: a favourable prognostic marker across molecular subtypes and independent of adjuvant therapy received
Sarah-Jane Dawson,N. Makretsov,Fiona M. Blows,Kristy Driver,Elena Provenzano,J. Le Quesne,Laura Baglietto,Laura Baglietto,Gianluca Severi,Gianluca Severi,Graham G. Giles,Graham G. Giles,Catriona McLean,Grace Callagy,Andrew R. Green,Ian O. Ellis,Karen A. Gelmon,Gulisa Turashvili,Samuel Leung,Samuel Aparicio,David G. Huntsman,Carlos Caldas,Paul D.P. Pharoah +22 more
TL;DR: BCL2 is an independent indicator of favourable prognosis for all types of early-stage breast cancer and the rationale for introduction of BCL2 immunohistochemistry to improve prognostic stratification is established.
Journal ArticleDOI
Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer
Gavin Ha,Gavin Ha,Andrew Roth,Andrew Roth,Daniel Lai,Ali Bashashati,Jiarui Ding,Jiarui Ding,Rodrigo Goya,Rodrigo Goya,Ryan Giuliany,Ryan Giuliany,Jamie Rosner,Arusha Oloumi,Karey Shumansky,Suet-Feung Chin,Gulisa Turashvili,Martin Hirst,Carlos Caldas,Marco A. Marra,Samuel Aparicio,Samuel Aparicio,Sohrab P. Shah,Sohrab P. Shah +23 more
TL;DR: It is shown that the majority of monoallelic expression in the transcriptomes of triple-negative breast cancer can be explained by genomic regions of LOH and an upper bound for monoalle Alic expression is established that may be explaining by other tumor-specific modifications such as epigenetics or mutations.