C
Carlos Caldas
Researcher at University of Cambridge
Publications - 573
Citations - 86546
Carlos Caldas is an academic researcher from University of Cambridge. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 122, co-authored 547 publications receiving 73840 citations. Previous affiliations of Carlos Caldas include Institute of Cancer Research & University of Münster.
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Lymphocyte density determined by computational pathology validated as a predictor of response to neoadjuvant chemotherapy in breast cancer: secondary analysis of the ARTemis trial
Ali Hr,Aliakbar Dariush,Jeremy Thomas,Elena Provenzano,Elena Provenzano,Janet A. Dunn,Louise Hiller,A-L Vallier,Jean Abraham,T Piper,Jms Bartlett,Jms Bartlett,David Cameron,Larry Hayward,James D. Brenton,Paul D.P. Pharoah,Mike Irwin,Nicholas A. Walton,Helena M. Earl,Carlos Caldas +19 more
TL;DR: Lymphocyte density in pre-treatment biopsies was validated as an independent predictor of pCR in breast cancer and Computational pathology is emerging as a viable and objective means of identifying predictive biomarkers for cancer patients.
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Tamoxifen: the drug that came in from the cold
TL;DR: The current evidence strongly supports the view that AIs should be used 2–3 years after tamoxifen to achieve the maximal overall survival (OS) advantage.
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The breast cancer somatic 'muta-ome': tackling the complexity.
TL;DR: In this paper, the authors identified a surprising richness of low-frequency mutants contrasting with the relative rarity of high-frequency events and a relatively large number of somatic genomic aberrations (approximately 20 to 50) driving an average tumour.
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Astronomical algorithms for automated analysis of tissue protein expression in breast cancer
Ali Hr,Mike Irwin,Lorna Morris,Sarah-Jane Dawson,Fiona M. Blows,Elena Provenzano,Betania Mahler-Araujo,Paul D.P. Pharoah,Nicholas A. Walton,James D. Brenton,Carlos Caldas +10 more
TL;DR: The adaptation of astronomical algorithms coupled with their application to large annotated study cohorts, constitutes a powerful tool for the realisation of the enormous potential of digital pathology.
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Navigator‐3, a modulator of cell migration, may act as a suppressor of breast cancer progression
Hadas Cohen-Dvashi,Nir Ben-Chetrit,Roslin Russell,Silvia Carvalho,Mattia Lauriola,Sophia Nisani,Maicol Mancini,Nishanth Belugali Nataraj,Merav Kedmi,Lee Roth,Wolfgang J. Köstler,Amit Zeisel,Assif Yitzhaky,Jacques Zylberg,Gabi Tarcic,Raya Eilam,Yoav Wigelman,Rainer Will,Sara Lavi,Ziv Porat,Stefan Wiemann,Sara Ricardo,Fernando Schmitt,Carlos Caldas,Yosef Yarden +24 more
TL;DR: It is proposed that NAV3 inhibits breast cancer progression by regulating microtubule dynamics, biasing directionally persistent rather than random migration, and inhibiting locomotion of initiated cells.