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Carmen Domene
Researcher at University of Bath
Publications - 124
Citations - 3841
Carmen Domene is an academic researcher from University of Bath. The author has contributed to research in topics: KcsA potassium channel & Ion channel. The author has an hindex of 33, co-authored 118 publications receiving 3405 citations. Previous affiliations of Carmen Domene include University of Bologna & University of Pennsylvania.
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Journal ArticleDOI
Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases
Rasheduzzaman Chowdhury,Michael A. McDonough,Jasmin Mecinović,Christoph Loenarz,Emily Flashman,Kirsty S. Hewitson,Carmen Domene,Christopher J. Schofield +7 more
TL;DR: In this paper, crystal structures of the catalytic domain of PHD2, the most important of the human PHDs, in complex with the C-terminal oxygen-dependent degradation domain of HIF-1alpha.
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Pentagon adjacency as a determinant of fullerene stability
E Albertazzi,Carmen Domene,P.W. Fowler,Thomas Heine,Gotthard Seifert,C. Van Alsenoy,Francesco Zerbetto +6 more
TL;DR: In this article, the optimal configuration of all 40 fullerene isomers of C40, using methods from molecular mechanics and tight-binding to full abinitio SCF and DFT approaches, confirms minimisation of pentagon adjacency as a major factor in relative stability.
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Ion channel gating: insights via molecular simulations.
Oliver Beckstein,Philip C. Biggin,Peter J. Bond,Joanne N. Bright,Carmen Domene,Alessandro Grottesi,John Holyoake,Mark S.P. Sansom +7 more
TL;DR: Modelling and simulation studies confirm the importance of hydrophobic gating in K channels, and support a model in which hinge‐bending of the pore‐lining M2 (or S6 in Kv channels) helices underlies channel gating.
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Two Different Conformational States of the KirBac3.1 Potassium Channel Revealed by Electron Crystallography
TL;DR: Analysis by electron cryomicroscopy of 2D crystals of the inwardly rectifying K(+) channel KirBac3.1 from Magnetospirillum magnetotacticum have been captured in two distinct conformations, providing "snap shots" of the gating process.
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Potassium channel, ions, and water: simulation studies based on the high resolution X-ray structure of KcsA
Carmen Domene,Mark S.P. Sansom +1 more
TL;DR: In this article, the authors investigated the interactions of Na+, K+, Rb+, and Cs+ ions within the selectivity filter of a potassium channel via multiple molecular dynamics simulations (total simulation time, 48 ns).