C
Carmen Lategan
Researcher at University of Cape Town
Publications - 32
Citations - 1072
Carmen Lategan is an academic researcher from University of Cape Town. The author has contributed to research in topics: Plasmodium falciparum & Dihydroartemisinin. The author has an hindex of 19, co-authored 32 publications receiving 975 citations. Previous affiliations of Carmen Lategan include North-West University.
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Journal ArticleDOI
Synthesis, antimalarial and antitubercular activity of acetylenic chalcones
Renate H. Hans,Eric M. Guantai,Carmen Lategan,Pete Smith,Baojie Wan,Scott G. Franzblau,Jiri Gut,Philip J. Rosenthal,Kelly Chibale +8 more
TL;DR: The antimalarial data for this series suggests that growth inhibition of the W2 strain of Plasmodium falciparum can be imparted by the introduction of a methoxy group ortho to the acetylenic group.
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Synthesis, Structure and in Vitro Biological Screening of Palladium(II) Complexes of Functionalised Salicylaldimine Thiosemicarbazones as Antimalarial and Anticancer Agents
Prinessa Chellan,Nelusha Shunmoogam-Gounden,Denver T. Hendricks,Jiri Gut,Philip J. Rosenthal,Carmen Lategan,Pete Smith,Kelly Chibale,Gregory S. Smith +8 more
TL;DR: A series of mononuclear salicylaldiminato(thiosemicarbazone)palladium(II) complexes of general formula [Pd(saltsc-R)PPh 3 ], {H 2 saltsc-r = sicylaldehyde thiosembrazone; R = H (5), 3tert-butyl (6), 3-methoxy (7), 5-chloro (8)) have been synthesized as mentioned in this paper.
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Fucoxanthin, tetraprenylated toluquinone and toluhydroquinone metabolites from Sargassum heterophyllum inhibit the in vitro growth of the malaria parasite Plasmodium falciparum.
TL;DR: Fucoxanthin and sargaquinal showed good antiplasmodial activity toward a chloroquine-sensitive strain (D10) of Plasmodium falciparum of Sargassum heterophyllum.
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Antiplasmodial activity of aporphine alkaloids and sesquiterpene lactones from Liriodendron tulipifera L.
Rocky Graziose,Thirumurugan Rathinasabapathy,Carmen Lategan,Alexander Poulev,Pete Smith,Mary H. Grace,Mary Ann Lila,Ilya Raskin +7 more
TL;DR: In this paper, the active constituents of the traditionally used antimalarial plant Liriodendron tulipifera by antiplasmodial-assay guided fractionation were identified.
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Synthesis and in vitro evaluation of gold(I) thiosemicarbazone complexes for antimalarial activity
Setshaba D. Khanye,Gregory S. Smith,Carmen Lategan,Pete Smith,Jiri Gut,Philip J. Rosenthal,Kelly Chibale +6 more
TL;DR: The in vitro antimalarial data for gold(I) TSC complexes suggests that coordination of gold( I) to TSCs enhanced their efficacy against the malaria parasite Plasmodium falciparum and their inhibition of the parasite cysteine protease falCipain-2.