Carole R. Rickards

TL;DR: It is shown that, independently of the transporter associated with antigen processing, gpUL40 can up-regulate expression of HLA-E, which protects targets from NK cell lysis, which is up-regulated by HCMV.

TL;DR: It is shown that the viral UL141 gene product has an immunomodulatory function that is associated with low-passage strains of human cytomegalovirus.

TL;DR: The mechanisms by which HCMV systematically evades (or, more properly, modulates) NK cell recognition constitutes an area of growing understanding that is enhancing the authors' appreciation of the basic mechanisms of NK cell function in humans.

TL;DR: In this study, LIR-1+ NKL cell-mediated cytotoxicity was shown to be inhibited by transduction of targets with a replication-deficient adenovirus vector encoding UL18 (RAd-UL18) and fibroblasts infected with an HCMV UL18 mutant also exhibited enhanced susceptibility to NKL killing relative to cells infected with the parental virus.

TL;DR: The interaction of IE1(491aa) with chromatin was therefore not required for the disruption of PML-bodies, and both PML and IE1 were observed to associate with mitotic chromosomes in cells infected with HCMV or transfected with the IE1 gene.