C
Carolina Berger
Researcher at Fred Hutchinson Cancer Research Center
Publications - 55
Citations - 5779
Carolina Berger is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: CD8 & Antigen. The author has an hindex of 26, co-authored 50 publications receiving 4651 citations. Previous affiliations of Carolina Berger include University of Washington & University of Hamburg.
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Journal ArticleDOI
CD19 CAR–T cells of defined CD4+:CD8+ composition in adult B cell ALL patients
Cameron J. Turtle,Laïla Aïcha Hanafi,Carolina Berger,Ted Gooley,Sindhu Cherian,Michael Hudecek,Daniel Sommermeyer,Katherine Melville,Barbara S. Pender,Tanya M Budiarto,Emily Robinson,Natalia N Steevens,Colette Chaney,Lorinda Soma,Xueyan Chen,Cecilia Yeung,Brent L. Wood,Daniel Li,Jianhong Cao,Shelly Heimfeld,Michael C. Jensen,Stanley R. Riddell,David G. Maloney +22 more
TL;DR: It is established that high CAR-T cell doses and tumor burden increase the risks of severe cytokine release syndrome and neurotoxicity, and serum biomarkers that allow testing of early intervention strategies in patients at the highest risk of toxicity are identified.
Journal ArticleDOI
Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates.
Carolina Berger,Michael C. Jensen,Peter M. Lansdorp,Mike Gough,Carole Elliott,Stanley R. Riddell +5 more
TL;DR: It is demonstrated that clonally derived CD8+ T cells isolated from central memory T cells are distinct from those derived from effectorMemory T cells and retain an intrinsic capacity that enables them to survive after adoptive transfer and revert to the memory cell pool.
Journal ArticleDOI
Immunotherapy of non-Hodgkin’s lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor–modified T cells
Cameron J. Turtle,Cameron J. Turtle,Laila-Aicha Hanafi,Carolina Berger,Carolina Berger,Michael Hudecek,Barbara S. Pender,Emily Robinson,Reed M. Hawkins,Colette Chaney,Sindhu Cherian,Xueyan Chen,Lorinda Soma,Brent L. Wood,Daniel Li,Shelly Heimfeld,Stanley R. Riddell,Stanley R. Riddell,David G. Maloney,David G. Maloney +19 more
TL;DR: Immunotherapy with CD19 CAR-T cells in a defined CD4+/CD8+ ratio allowed identification of correlative factors for CAR-t cell expansion, persistence, and toxicity, and facilitated optimization of lymphodepletion that improved disease response and overall and progression-free survival.
Journal ArticleDOI
Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK–modified donor T cells after allogeneic hematopoietic cell transplantation
Carolina Berger,Carolina Berger,Mary E.D. Flowers,Mary E.D. Flowers,Edus H. Warren,Edus H. Warren,Stanley R. Riddell,Stanley R. Riddell +7 more
TL;DR: The need for nonimmunogenic suicide genes are demonstrated, a strategy for detection of CD4+ and CD8+ T-cell responses to transgene products that should be generally applicable to monitoring patients on gene therapy trials is identified, and the potency of gene-modified T cells to elicit robust and durable immune responses is implied.
Journal ArticleDOI
Combining a CD20 chimeric antigen receptor and an inducible caspase 9 suicide switch to improve the efficacy and safety of T cell adoptive immunotherapy for lymphoma.
Lihua E. Budde,Lihua E. Budde,Lihua E. Budde,Carolina Berger,Yukang Lin,Jinjuan Wang,Xubin Lin,Shani E. Frayo,Shaunda A. Brouns,David M. Spencer,Brian G. Till,Brian G. Till,Michael C. Jensen,Michael C. Jensen,Stanley R. Riddell,Stanley R. Riddell,Stanley R. Riddell,Oliver W. Press,Oliver W. Press +18 more
TL;DR: Genetically modified human T cells with a lentiviral vector to express a CD20-CAR containing both CD28 and CD137 co-stimulatory domains, a “suicide gene” relying on inducible activation of caspase 9 (iC9), and a truncated CD19 selectable marker resulted in efficient removal of transduced T cells both in vitro and in vivo.