Carolyn B. Coyne

TL;DR: It is shown that RNAi-mediated depletion of FAM134B significantly enhances both DENV and ZIKV replication at an early stage of the viral life cycle, suggesting that these viruses specifically target these pathways to promote viral replication.

TL;DR: A model of gestational stage dependence of ZIKV pathogenesis and IFN-λ-mediated immunity at the maternal-fetal interface is established and is established as a basis for future research on Zika virus-induced congenital disease.

TL;DR: It is shown that respiratory viral infections and the induction of antiviral interferons promote robust secondary P. aeruginosa biofilm formation through a mechanism of dysregulated iron homeostasis of the airway epithelium, and nutritional immunity pathways that are disrupted during respiratory viral infection create an environment that favors secondary bacterial infection and may provide previously unidentified targets to combat bacterialBiofilm formation.

TL;DR: The results suggest that the specific localization pattern of CLDN1 may be crucial in the regulation of HCV cellular tropism.

TL;DR: These studies provide insights into enterovirus infections of the human intestine, which could lead to the identification of novel therapeutic targets and/or strategies to prevent or treat infections by these highly clinically relevant viruses.