C
Carolyn B. Coyne
Researcher at University of Pittsburgh
Publications - 120
Citations - 13342
Carolyn B. Coyne is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Viral replication & Trophoblast. The author has an hindex of 45, co-authored 105 publications receiving 11154 citations. Previous affiliations of Carolyn B. Coyne include University of Alabama at Birmingham & Boston Children's Hospital.
Papers
More filters
Journal ArticleDOI
Type I interferons instigate fetal demise after Zika virus infection
Laura J. Yockey,Kellie A. Jurado,Nitin Arora,Alon Millet,Tasfia Rakib,Kristin M. Milano,Andrew K. Hastings,Erol Fikrig,Erol Fikrig,Yong Kong,Tamas L. Horvath,Scott D. Weatherbee,Harvey J. Kliman,Carolyn B. Coyne,Akiko Iwasaki,Akiko Iwasaki +15 more
TL;DR: The results implicate type I IFNs as a possible mediator of pregnancy complications, including spontaneous abortions and growth restriction, in the context of congenital viral infections.
Journal ArticleDOI
Review: placenta-specific microRNAs in exosomes - good things come in nano-packages.
TL;DR: The function of miRNAs from the primate-specific chromosome 19 miRNA cluster that originate in trophoblasts and that could mediate crosstalk between the feto-placental unit and the mother during pregnancy are detailed.
Journal ArticleDOI
MicroRNAs in placental health and disease
TL;DR: Key findings in the field are summarized, current knowledge related to miRNAs in the context of placental biology is discussed and current knowledge regarding their role in clinical practice is discussed.
Journal ArticleDOI
Mechanisms of MAVS regulation at the mitochondrial membrane.
Jana L. Jacobs,Carolyn B. Coyne +1 more
TL;DR: This review focuses on the MAVS regulome and review the cellular factors that regulate MAVS by protein-protein interactions, alterations in mitochondrial dynamics, and/or post-translational modifications.
Journal ArticleDOI
Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus
Keiko Rausch,Brent A. Hackett,Nathan L. Weinbren,Sophia M. Reeder,Yoel Sadovsky,Christopher A. Hunter,David C. Schultz,Carolyn B. Coyne,Sara Cherry +8 more
TL;DR: Nanchangmycin was identified as a potent inhibitor of Zika virus entry across all cell types tested, including physiologically relevant primary cells, and was active against other medically relevant viruses, including West Nile, dengue, and chikungunya viruses that use a similar route of entry.