Carolyn M. Hannan

TL;DR: DNA priming followed by MVA boosting may provide a general immunization regime for induction of high levels of CD8+ T cells and was abrogated when the order of immunization was reversed.

TL;DR: It is shown that a heterologous prime-boost vaccination regime of DNA either intramuscularly or epidermally, followed by intradermal recombinant modified vaccinia virus Ankara (MVA), induces high frequencies of interferon-γ-secreting, antigen-specific T-cell responses in humans to a pre-erythrocytic malaria antigen, thrombospondin-related adhesion protein (TRAP).

TL;DR: It is shown that recombinant modified vaccinia virus Ankara, expressing Mycobacterium tuberculosis Ag 85A (M.85A), strongly boosts bacille Calmette-Guérin (BCG)-induced Ag85A specific CD4+ and CD8+ T cell responses in mice, which support further evaluation of mucosally targeted prime-boost vaccination approaches for tuberculosis.

TL;DR: A combined regime whereby the animals were first primed with the DNA vaccine and then boosted with MVA was the most potent protocol for the induction of both interferon-gamma-producing and cytolytic T cells against two CTL epitopes simultaneously.

TL;DR: This review provides an overview of prime‐boost immunisation strategies that result in protective CD8’ T‐cell responses against malaria with an emphasis on work from the laboratory.