C
Carsten W. Lederer
Researcher at The Cyprus Institute of Neurology and Genetics
Publications - 58
Citations - 2316
Carsten W. Lederer is an academic researcher from The Cyprus Institute of Neurology and Genetics. The author has contributed to research in topics: Genome editing & CRISPR. The author has an hindex of 20, co-authored 53 publications receiving 2045 citations. Previous affiliations of Carsten W. Lederer include Norwich Research Park & John Innes Centre.
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A Viral Movement Protein Prevents Spread of the Gene Silencing Signal in Nicotiana benthamiana
TL;DR: It is demonstrated with potato virus X (PVX) that PTGS operates as a systemic, sequence-specific defense system, but in grafting experiments or with movement defective forms of PVX, it could not detect systemic silencing unless the 25 kDa viral movement protein (p25) was made nonfunctional.
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Turnip crinkle virus coat protein mediates suppression of RNA silencing in Nicotiana benthamiana.
TL;DR: All of the protein products of Turnip crinkle virus were tested for their ability to suppress RNA silencing of a reporter gene after transient expression in Agrobacterium-infiltrated Nicotiana benthamiana leaves, and only the capsid protein, P38, showed suppression activity.
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IthaGenes: an interactive database for haemoglobin variations and epidemiology.
Petros Kountouris,Carsten W. Lederer,Pavlos Fanis,Xenia Feleki,John M. Old,Marina Kleanthous +5 more
TL;DR: IthaGenes is a new interactive database of haemoglobin variations, which stores information about genes and variations affecting ha Hemoglobin disorders, while embedding the NCBI Sequence Viewer for graphical representation of each variation.
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Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis
TL;DR: Gene and sample numbers investigated allow pathway- and gene-based analyses by established error-correction methods, drawing a molecular portrait of the ALS motor cortex that faithfully represents many known disease features and uncovers several novel aspects of ALS pathology.
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The dialogue between viruses and hosts in compatible interactions.
TL;DR: This work has begun to map out the relationships of its component parts, and the picture that emerges is one in which host gene expression and physiology are under tight temporal control during infection.