P
Pavlos Fanis
Researcher at The Cyprus Institute of Neurology and Genetics
Publications - 45
Citations - 1028
Pavlos Fanis is an academic researcher from The Cyprus Institute of Neurology and Genetics. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 10, co-authored 35 publications receiving 800 citations. Previous affiliations of Pavlos Fanis include Erasmus University Rotterdam.
Papers
More filters
Journal ArticleDOI
Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin
Joseph Borg,Petros Papadopoulos,Marianthi Georgitsi,Laura Gutierrez,Godfrey Grech,Godfrey Grech,Pavlos Fanis,Marios Phylactides,Annemieke J.M.H. Verkerk,Peter J. van der Spek,Christian Scerri,Christian Scerri,Wilhelmina Cassar,Wilhelmina Cassar,Ruth Galdies,Ruth Galdies,Wilfred F. J. van IJcken,Zeliha Ozgur,Nynke Gillemans,Jun Hou,Marisa Bugeja,Marisa Bugeja,Frank Grosveld,Marieke von Lindern,Alex E. Felice,Alex E. Felice,George P. Patrinos,Sjaak Philipsen +27 more
TL;DR: Functional assays suggested that, in addition to its established role in regulating adult globin expression, KLF1 is a key activator of the BCL11A gene, which encodes a suppressor of HbF expression.
Journal ArticleDOI
IthaGenes: an interactive database for haemoglobin variations and epidemiology.
Petros Kountouris,Carsten W. Lederer,Pavlos Fanis,Xenia Feleki,John M. Old,Marina Kleanthous +5 more
TL;DR: IthaGenes is a new interactive database of haemoglobin variations, which stores information about genes and variations affecting ha Hemoglobin disorders, while embedding the NCBI Sequence Viewer for graphical representation of each variation.
Journal ArticleDOI
Oxidative stress in β-thalassaemia and sickle cell disease
TL;DR: An overview of the main players and control mechanisms involved in the establishment of oxidative stress in these haemoglobinopathies is provided.
Journal ArticleDOI
Five Friends of Methylated Chromatin Target of Protein-Arginine-Methyltransferase[Prmt]-1 (Chtop), a Complex Linking Arginine Methylation to Desumoylation
Pavlos Fanis,Nynke Gillemans,Ali Aghajanirefah,Farzin Pourfarzad,Jeroen Demmers,Fatemehsadat Esteghamat,Ratna K. Vadlamudi,Frank Grosveld,Sjaak Philipsen,Thamar B. van Dijk +9 more
TL;DR: The identification and initial characterization of Five Friends of Methylated Chtop (5FMC) and recruitment of 5FMC to Zbp-89, a zinc-finger transcription factor, affects its sumoylation status and transactivation potential provide a mechanistic link between arginine methylation and (de)sumoylation in the control of transcriptional activity.
Journal ArticleDOI
Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases.
Thamar B. van Dijk,Nynke Gillemans,Claudia Stein,Pavlos Fanis,Jeroen Demmers,Mariëtte van de Corput,Jeroen Essers,Frank Grosveld,Uta-Maria Bauer,Sjaak Philipsen +9 more
TL;DR: It is shown that Fop is tightly associated with chromatin, and that it is modified by both asymmetric and symmetric arginine methylation in vivo, and plays an important role in the ligand-dependent activation of estrogen receptor target genes, including TFF1 (pS2).