Caterina Capperucci

TL;DR: It is confirmed that in the long bones of newborn mice, VEGF-D and VEGFR-3 are expressed in the osteoblasts of the growing plate and suggested that VEGf-D is a downstream effector of VEGFs in osteogenesis and plays a critical role in osteoblast maturation.

TL;DR: Changes in expression profiles for 17 proteins were ascertained in human mature osteoblasts compared to pre‐osteoblasts, and suggested caution on the use of osteosarcoma to study anti-osteoporotic drugs in humans.

TL;DR: The results show that neridronate does not negatively affect in vitro the viability, proliferation, and cellular activity of normal human osteoblasts even after a long period addition of the drug (20 days) at concentrations equal or lower than 10(-5) mol/l (therapeutic dose).

TL;DR: It is shown that OGP (10–14) can increase OPG secretion and can restore the altered expression of OPG induced by GCs to physiological levels and support the employment of OGP in clinical trials addressed to the treatment of different bone remodeling alterations including the GC‐induced osteoporosis.

TL;DR: SSc patients had reduced BMD and SI that was more marked in the diffuse form and in those with internal organ involvement and that became more marked with age and estrogen deficiency.