Bruno Frediani

TL;DR: The GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2244 critically ill Covid-19 patients from 208 UK intensive care units is reported, finding evidence in support of a causal link from low expression of IFNAR2, and high expression of TYK2, to life-threatening disease.

TL;DR: Evidence is provided that people living in an area with high levels of pollutant are more prone to develop chronic respiratory conditions and suitable to any infective agent, and the high level of pollution in Northern Italy should be considered an additional co-factor of the highlevel of lethality recorded in that area.

TL;DR: Eight out of nine refractory BD patients showed a prompt improvement after starting anakinra, supporting the concept that IL-1 plays a pathological role in this disease.

TL;DR: Treatment with IL-1 inhibitors is effective in the management of Behçet’s disease-related uveitis and provides a long-term control of ocular inflammation in refractory and long-lasting cases.

TL;DR: A positive family history for pericarditis or periodic fever syndromes, a poor response to colchicine, recurrences after the first year from the index attack or on colchichine treatment, as well as the need of immunosuppressive agents are clues of the possible presence of TNFRSF1A gene mutations in patients with recurrent pericARDitis.