Catharina de Lange Davies

TL;DR: It is shown that within a 24-hour period PBCA nanoparticles degraded significantly inside cells, releasing their payload into the cytosol, while POCA nanop articles remained intact, indicating that it is possible to tune the intracellular drug release rate by choosing appropriate monomers from the PACA family or by using hybrid PACA nanoparticle containing different monomers.

TL;DR: Accumulation in the tumor occurred more rapidly for the targeted nanoemulsions than for the nontargeted versions, and the PEG surface density had a strong effect on nanoparticle targeting efficiency.

TL;DR: Tailoring of the chain length and the substitution of chitosan were shown to be feasible tools to modulate the electrostatic interactions between the chitOSan and DNA and to design ch itosan vectors with an optimized balance between polyplex stability and polyplex unpacking.

TL;DR: The results show that chemoirradiation with Caelyx induces synergistic treatment effects, and improved intratumoral drug uptake and distribution are responsible for the enhanced antitumor effect.

TL;DR: In vivo FRET imaging is used to systematically investigate how drug–carrier compatibility affects drug release in a tumour mouse model and finds the drug's hydrophobicity and miscibility with the nanoparticles are two independent key parameters that determine its accumulation in the tumour.