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Astrid Bjørkøy
Researcher at Norwegian University of Science and Technology
Publications - 24
Citations - 472
Astrid Bjørkøy is an academic researcher from Norwegian University of Science and Technology. The author has contributed to research in topics: Microbubbles & Targeted drug delivery. The author has an hindex of 8, co-authored 23 publications receiving 376 citations.
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Journal ArticleDOI
Augmenting drug–carrier compatibility improves tumour nanotherapy efficacy
Yiming Zhao,Francois Fay,Sjoerd Hak,Jose Manuel Perez-Aguilar,Jose Manuel Perez-Aguilar,Brenda L. Sanchez-Gaytan,Brandon Goode,Raphaël Duivenvoorden,Catharina de Lange Davies,Astrid Bjørkøy,Harel Weinstein,Zahi A. Fayad,Carlos Pérez-Medina,Willem J. M. Mulder +13 more
TL;DR: In vivo FRET imaging is used to systematically investigate how drug–carrier compatibility affects drug release in a tumour mouse model and finds the drug's hydrophobicity and miscibility with the nanoparticles are two independent key parameters that determine its accumulation in the tumour.
Journal ArticleDOI
Cellular uptake of DNA-chitosan nanoparticles: the role of clathrin- and caveolae-mediated pathways
Zuzana Garaiova,Sabina P. Strand,Nina Kristine Reitan,Sylvie Lelu,Sigmund Ø. Størset,Kristian Berg,Jostein Malmo,Oladayo Folasire,Astrid Bjørkøy,Catharina de Lange Davies +9 more
TL;DR: This work tailored chitosan to optimize it for transfection by synthesizing self-branched and trisaccharide-substituted chitOSan oligomers (SBTCO), which show superior transfections efficacy compared with linear chitposan (LCO).
Journal ArticleDOI
Ultrasound Improves the Delivery and Therapeutic Effect of Nanoparticle-Stabilized Microbubbles in Breast Cancer Xenografts.
Sofie Snipstad,Sigrid Berg,Ýrr Mørch,Astrid Bjørkøy,Einar Sulheim,Rune Hansen,Ingeborg Hovde Grimstad,Annemieke van Wamel,Astri F. Maaland,Sverre H. Torp,Catharina de Lange Davies +10 more
TL;DR: A unique multifunctional drug delivery system consisting of microbubbles stabilized by polymeric nanoparticles (NPMBs), enabling ultrasound-mediated drug delivery is investigated, to determine if increased tumor uptake had a therapeutic benefit.
Journal Article
Effect of collagenase and hyaluronidase on free and anomalous diffusion in multicellular spheroids and xenografts.
TL;DR: The results indicate that the collagen network has a greater impact on the interstitial diffusion of macromolecules in tumour tissue than the hyaluronan gel.
Journal ArticleDOI
Ruthenium porphyrin-induced photodamage in bladder cancer cells
Vanya Bogoeva,Monica Siksjø,Kristin G. Sæterbø,Thor Bernt Melø,Astrid Bjørkøy,Mikael Lindgren,Mikael Lindgren,Odrun A. Gederaas +7 more
TL;DR: The present investigation of RuP-PDT showed that the dominating mode of cell death is necrosis, and RuP "dark toxicity" compared to the conventional chemotherapeutic drug cisplatin was higher, both evaluated by the MTT assay (24h).