C
Catherine Maclachlan
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 23
Citations - 481
Catherine Maclachlan is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 9, co-authored 16 publications receiving 293 citations. Previous affiliations of Catherine Maclachlan include Francis Crick Institute.
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Journal ArticleDOI
Altered interplay between endoplasmic reticulum and mitochondria in Charcot–Marie–Tooth type 2A neuropathy
Nathalie Bernard-Marissal,Nathalie Bernard-Marissal,Gerben Van Hameren,Manisha Juneja,Christophe Pellegrino,Lauri Louhivuori,Luca Bartesaghi,Cylia Rochat,Omar El Mansour,Jean-Jacques Médard,Marie Croisier,Catherine Maclachlan,Olivier Poirot,Per Uhlén,Vincent Timmerman,Nicolas Tricaud,Bernard L. Schneider,Roman Chrast +17 more
TL;DR: In this article, mutations in the MFN2 gene encoding Mitofusin 2 lead to the development of Charcot-Marie-Tooth type 2A (CMT2A), a dominant axonal form of peripheral neuropathy.
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An intracellular replication niche for Vibrio cholerae in the amoeba Acanthamoeba castellanii.
TL;DR: The concept that V. cholerae is a facultative intracellular bacterium is reinforced and a new host–pathogen interaction is described, which describes a newhost– Pathogen interaction at the single-cell level.
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Mfn1 Deficiency in the Liver Protects Against Diet-Induced Insulin Resistance and Enhances the Hypoglycemic Effect of Metformin
Sameer S. Kulkarni,Magali Joffraud,Marie Boutant,Joanna Ratajczak,Joanna Ratajczak,Arwen W. Gao,Catherine Maclachlan,María Isabel Hernández-Alvarez,María Isabel Hernández-Alvarez,Frederic Raymond,Sylviane Metairon,Patrick Descombes,Riekelt H. Houtkooper,Antonio Zorzano,Antonio Zorzano,Carles Cantó,Carles Cantó +16 more
TL;DR: The results suggest that targeting Mfn1 could provide novel avenues to ameliorate glucose homeostasis in obese patients and improve the effectiveness of metformin.
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Molecular insights into Vibrio cholerae's intra-amoebal host-pathogen interactions.
Charles Van der Henst,Audrey S. Vanhove,Natalia Carolina Drebes Dörr,Sandrine Stutzmann,Candice Stoudmann,Stephanie Clerc,Tiziana Scrignari,Catherine Maclachlan,Graham Knott,Melanie Blokesch +9 more
TL;DR: It is demonstrated that minor virulence features important for disease in mammals, such as extracellular enzymes and flagellum-based motility, have a key role in the replication and transmission of V. cholerae in its aqueous environment.
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Differences in cisplatin distribution in sensitive and resistant ovarian cancer cells: a TEM/NanoSIMS study
Ronald F. S. Lee,Tina Riedel,Stéphane Escrig,Catherine Maclachlan,Graham Knott,Curt A. Davey,Kai Johnsson,Anders Meibom,Anders Meibom,Paul J. Dyson +9 more
TL;DR: A combination of transmission electron microscopy (TEM) and nanoscale-secondary ion mass spectrometry (NanoSIMS) is used to reveal differences between cisplatin uptake in human ovarian cancers cells, which are known to be susceptible to acquired resistance to cisPlatin.