G
Graham Knott
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 176
Citations - 16269
Graham Knott is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Dendritic spine & Synapse. The author has an hindex of 53, co-authored 169 publications receiving 14133 citations. Previous affiliations of Graham Knott include University of Tasmania & École Polytechnique.
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Journal ArticleDOI
Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
Joshua T. Trachtenberg,Brian E. Chen,Graham Knott,Guoping Feng,Joshua R. Sanes,Egbert Welker,Karel Svoboda +6 more
TL;DR: The measurements suggest that sensory experience drives the formation and elimination of synapses and that these changes might underlie adaptive remodelling of neural circuits.
Journal ArticleDOI
Transient and Persistent Dendritic Spines in the Neocortex In Vivo
Anthony Holtmaat,Joshua T. Trachtenberg,Linda Wilbrecht,Gordon M. Shepherd,Xiaoqun Zhang,Graham Knott,Karel Svoboda +6 more
TL;DR: In 6-month-old mice, spines turn over more slowly in visual compared to somatosensory cortex, possibly reflecting differences in the capacity for experience-dependent plasticity in these brain regions.
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Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window
Anthony Holtmaat,Anthony Holtmaat,Tobias Bonhoeffer,David K. Chow,JA Chuckowree,Vincenzo De Paola,Vincenzo De Paola,Sonja B. Hofer,Sonja B. Hofer,Mark Hübener,Tara Keck,Graham Knott,Graham Knott,Wei-Chung Allen Lee,Ricardo Mostany,Thomas D. Mrsic-Flogel,Thomas D. Mrsic-Flogel,Elly Nedivi,Carlos Portera-Cailliau,Karel Svoboda,Karel Svoboda,Joshua T. Trachtenberg,Linda Wilbrecht,Linda Wilbrecht +23 more
TL;DR: A chronic cranial window is described to obtain optical access to the mouse cerebral cortex for long-term imaging and the entire dendritic and axonal arbor of individual neurons can be reconstructed.
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Mitonuclear protein imbalance as a conserved longevity mechanism
Riekelt H. Houtkooper,Laurent Mouchiroud,Dongryeol Ryu,Norman Moullan,Elena Katsyuba,Graham Knott,Robert W. Williams,Johan Auwerx +7 more
TL;DR: It is demonstrated that MRPs represent an evolutionarily conserved protein family that ties the mitochondrial ribosome and mitonuclear protein imbalance to the mitochondrial unfolded protein response, an overarching longevity pathway across many species.
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Serial section scanning electron microscopy of adult brain tissue using focused ion beam milling.
TL;DR: This method uses different sectioning techniques to produce serial images suitable for seeing the smallest synaptic contacts within a volume of brain tissue using electron microscopy.