Catherine Whibley

TL;DR: Polymorphic variants of other genes in the p53 pathway, such as MDM2, which might have biological consequences either individually or in combination with p53 variants are discussed.

TL;DR: The causes of the excess of congenital anomalies in a large multiethnic birth cohort are identified and sensitive advice about the risks is provided to communities at increased risk, and to couples in consanguineous unions, to assist in reproductive decision making.

TL;DR: The Born in Bradford study as discussed by the authors showed that consanguinity is a major risk factor for congenital anomalies in children of Pakistani origin, and that the risk remains even after adjustment for deprivation, and accounts for almost a third of anomalies in babies of Pakistan origin.

TL;DR: In cell lines ensuing from benzo(a)pyrene-treated cultures the combined p53 mutation pattern showed a predominance of strand-biased G to T transversions, and mutations recurring at smokers' lung tumour hotspot codons 157 and 273, supporting involvement of tobacco carcinogens in shaping the mutation signature in lung cancers of smokers.

TL;DR: Various routes to p53/ARF disruption in senescence bypass are considered, and dysfunction of other tumour suppressor networks that may contribute to release from tenacious cell cycle arrest in senescent cultures are considered.