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Cedric Mombereau
Researcher at Novartis
Publications - 19
Citations - 3816
Cedric Mombereau is an academic researcher from Novartis. The author has contributed to research in topics: GABAB receptor & Metabotropic receptor. The author has an hindex of 16, co-authored 18 publications receiving 3520 citations. Previous affiliations of Cedric Mombereau include University of Pennsylvania & Hoffmann-La Roche.
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Journal ArticleDOI
The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice.
TL;DR: The tail suspension test is a useful test for assessing the behavioural effects of antidepressant compounds and other pharmacological and genetic manipulations relevant to depression.
Journal ArticleDOI
In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice.
John F. Cryan,Cedric Mombereau +1 more
TL;DR: It is suggested that it is prudent and most appropriate to use convergent tests that draw on different antidepressant-related endophenotypes, and complimentary physiological analyses in order to provide a program of information concerning whether a given phenotype is functionally relevant to depression-related pathology.
Journal ArticleDOI
Genetic and Pharmacological Evidence of a Role for GABA B Receptors in the Modulation of Anxiety- and Antidepressant-Like Behavior
Cedric Mombereau,Klemens Kaupmann,Wolfgang Froestl,Gilles Sansig,P. Herman van der Putten,John F. Cryan +5 more
TL;DR: Positive modulation of the GABAB receptors may serve as a novel therapeutic strategy for the development of anxiolytics, whereas GABAB receptor antagonism may service as a basis for the generation of novel antidepressants.
Journal ArticleDOI
A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo.
K Mitsukawa,Rina Yamamoto,Silvio Ofner,Joachim Nozulak,Oliver L. Pescott,Snezana Lukic,Natacha Stoehr,Cedric Mombereau,Rainer Kuhn,Kevin H. McAllister,P. Herman van der Putten,John F. Cryan,Peter J. Flor +12 more
TL;DR: An mGluR7-selective agonist, N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride (AMN082), which directly activates receptor signaling via an allosteric site in the transmembrane domain is characterized and provided evidence for full agonist activity mediated by the heptahelical domain of family 3 G protein-coupled receptors that may lead to drug development opportunities.
Journal ArticleDOI
Redistribution of GABAB(1) Protein and Atypical GABAB Responses in GABAB(2)-Deficient Mice
Martin Gassmann,Hamdy Shaban,Réjan Vigot,Gilles Sansig,Corinne Haller,Samuel Barbieri,Yann Humeau,Valerie Schuler,Matthias Müller,Bernd Kinzel,Klaus Klebs,Markus Schmutz,Wolfgang Froestl,Jakob Heid,Peter H. Kelly,Clive Gentry,Anne Lise Jaton,Herman van der Putten,Cedric Mombereau,Lucas Lecourtier,Johannes Mosbacher,John F. Cryan,Jean-Marc Fritschy,Andreas Lüthi,Klemens Kaupmann,Bernhard Bettler +25 more
TL;DR: The data suggest that association of GABAB(2) withGABAB(1) is essential for receptor localization in distal processes but is not absolutely necessary for signaling, and it is therefore possible that functional GABAB receptors exist in neurons that naturally lack GABAB (2) subunits.