M
Markus Schmutz
Researcher at Novartis
Publications - 80
Citations - 3705
Markus Schmutz is an academic researcher from Novartis. The author has contributed to research in topics: NMDA receptor & Anticonvulsant. The author has an hindex of 26, co-authored 80 publications receiving 3584 citations. Previous affiliations of Markus Schmutz include Ciba Specialty Chemicals.
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Journal ArticleDOI
Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1))
Valerie Schuler,Christian Lüscher,Christophe Blanchet,Norman Klix,Gilles Sansig,Klaus Klebs,Markus Schmutz,Jakob Heid,Clive Gentry,Laszlo Urban,Alyson Fox,Will P.J.M Spooren,Anne-Lise Jaton,Jean-Marie Vigouret,Mario F. Pozza,Peter H. Kelly,Johannes Mosbacher,Wolfgang Froestl,Edgar Käslin,Reinhard Korn,Serge Bischoff,Klemens Kaupmann,Herman van der Putten,Bernhard Bettler +23 more
TL;DR: It is demonstrated that Balb/c mice lacking the GABA(B(1)) subunit are viable, exhibit spontaneous seizures, hyperalgesia, hyperlocomotor activity, and memory impairment, and casts doubt on the existence of proposed receptor subtypes.
Journal Article
CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist.
John Lehmann,Hutchison Alan J,S E McPherson,C Mondadori,Markus Schmutz,C M Sinton,C Tsai,Deborah E. Murphy,D J Steel,Michael Williams +9 more
TL;DR: CGS 19755 (cis-4-phosphonomethyl-2-piperidine carboxylic acid) was found to be a potent, stereospecific inhibitor of N-methyl-D-aspartate (NMDA)-evokes, but not KCl-evoked, [3H] acetylcholine release from slices of the rat striatum, suggesting a competitive interaction with NMDA-type receptors.
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Redistribution of GABAB(1) Protein and Atypical GABAB Responses in GABAB(2)-Deficient Mice
Martin Gassmann,Hamdy Shaban,Réjan Vigot,Gilles Sansig,Corinne Haller,Samuel Barbieri,Yann Humeau,Valerie Schuler,Matthias Müller,Bernd Kinzel,Klaus Klebs,Markus Schmutz,Wolfgang Froestl,Jakob Heid,Peter H. Kelly,Clive Gentry,Anne Lise Jaton,Herman van der Putten,Cedric Mombereau,Lucas Lecourtier,Johannes Mosbacher,John F. Cryan,Jean-Marc Fritschy,Andreas Lüthi,Klemens Kaupmann,Bernhard Bettler +25 more
TL;DR: The data suggest that association of GABAB(2) withGABAB(1) is essential for receptor localization in distal processes but is not absolutely necessary for signaling, and it is therefore possible that functional GABAB receptors exist in neurons that naturally lack GABAB (2) subunits.
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5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition.
TL;DR: NMDA antagonists derived from 5-phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione (3a) are potent anticonvulsant agents, and display strong protective effects in the electroshock-induced convulsion assay in mice.
Journal ArticleDOI
Increased Seizure Susceptibility in Mice Lacking Metabotropic Glutamate Receptor 7
Gilles Sansig,Trevor J. Bushell,Vernon R. J. Clarke,Andrei Rozov,Nail Burnashev,C. Portet,Fabrizio Gasparini,Markus Schmutz,Klaus Klebs,Ryuichi Shigemoto,Peter J. Flor,Rainer Kuhn,Thomas Knoepfel,Markus Schroeder,David R. Hampson,Valerie J. Collett,Congxiao Zhang,Robert M. Duvoisin,Graham L. Collingridge,Herman van der Putten +19 more
TL;DR: It is suggested that mGluR7 receptors have a unique role in regulating neuronal excitability and that these receptors may be a novel target for the development of anticonvulsant drugs.