K
Klaus Klebs
Researcher at Novartis
Publications - 13
Citations - 1335
Klaus Klebs is an academic researcher from Novartis. The author has contributed to research in topics: GABAB receptor & Agonist. The author has an hindex of 9, co-authored 13 publications receiving 1273 citations.
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Journal ArticleDOI
Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1))
Valerie Schuler,Christian Lüscher,Christophe Blanchet,Norman Klix,Gilles Sansig,Klaus Klebs,Markus Schmutz,Jakob Heid,Clive Gentry,Laszlo Urban,Alyson Fox,Will P.J.M Spooren,Anne-Lise Jaton,Jean-Marie Vigouret,Mario F. Pozza,Peter H. Kelly,Johannes Mosbacher,Wolfgang Froestl,Edgar Käslin,Reinhard Korn,Serge Bischoff,Klemens Kaupmann,Herman van der Putten,Bernhard Bettler +23 more
TL;DR: It is demonstrated that Balb/c mice lacking the GABA(B(1)) subunit are viable, exhibit spontaneous seizures, hyperalgesia, hyperlocomotor activity, and memory impairment, and casts doubt on the existence of proposed receptor subtypes.
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Redistribution of GABAB(1) Protein and Atypical GABAB Responses in GABAB(2)-Deficient Mice
Martin Gassmann,Hamdy Shaban,Réjan Vigot,Gilles Sansig,Corinne Haller,Samuel Barbieri,Yann Humeau,Valerie Schuler,Matthias Müller,Bernd Kinzel,Klaus Klebs,Markus Schmutz,Wolfgang Froestl,Jakob Heid,Peter H. Kelly,Clive Gentry,Anne Lise Jaton,Herman van der Putten,Cedric Mombereau,Lucas Lecourtier,Johannes Mosbacher,John F. Cryan,Jean-Marc Fritschy,Andreas Lüthi,Klemens Kaupmann,Bernhard Bettler +25 more
TL;DR: The data suggest that association of GABAB(2) withGABAB(1) is essential for receptor localization in distal processes but is not absolutely necessary for signaling, and it is therefore possible that functional GABAB receptors exist in neurons that naturally lack GABAB (2) subunits.
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Increased Seizure Susceptibility in Mice Lacking Metabotropic Glutamate Receptor 7
Gilles Sansig,Trevor J. Bushell,Vernon R. J. Clarke,Andrei Rozov,Nail Burnashev,C. Portet,Fabrizio Gasparini,Markus Schmutz,Klaus Klebs,Ryuichi Shigemoto,Peter J. Flor,Rainer Kuhn,Thomas Knoepfel,Markus Schroeder,David R. Hampson,Valerie J. Collett,Congxiao Zhang,Robert M. Duvoisin,Graham L. Collingridge,Herman van der Putten +19 more
TL;DR: It is suggested that mGluR7 receptors have a unique role in regulating neuronal excitability and that these receptors may be a novel target for the development of anticonvulsant drugs.
Journal ArticleDOI
Specific γ-hydroxybutyrate-binding sites but loss of pharmacological effects of γ-hydroxybutyrate in GABAB(1)-deficient mice
Klemens Kaupmann,John F. Cryan,Petrine Wellendorph,Cedric Mombereau,Gilles Sansig,Klaus Klebs,Markus Schmutz,Wolfgang Froestl,Herman van der Putten,Johannes Mosbacher,Hans Bräuner-Osborne,Peter C. Waldmeier,Bernhard Bettler +12 more
TL;DR: It appears that all studied GHB effects are GABAB receptor dependent, and the GHB‐induced GTPγ[35S] responses are mediated by GABAB receptors.
Journal ArticleDOI
The competitive NMDA receptor antagonists CGP 37849 and CGP 39551 are potent, orally-active anticonvulsants in rodents.
Markus Schmutz,C. Portet,A. Jeker,Klaus Klebs,Annick Vassout,Hans Allgeier,Roland Heckendorn,Graham E. Fagg,H. R. Olpe,H. van Riezen +9 more
TL;DR: CGP 37849 and CGP 39551 are the first competitive NMDA antagonists to show oral anticonvulsant properties in a therapeutically-useful dose-range, and hence are interesting candidates for novel antiepileptic therapy in man.