H
Hsin-Yi Chen
Researcher at Wistar Institute
Publications - 19
Citations - 3260
Hsin-Yi Chen is an academic researcher from Wistar Institute. The author has contributed to research in topics: Autophagy & Programmed cell death. The author has an hindex of 8, co-authored 12 publications receiving 2928 citations. Previous affiliations of Hsin-Yi Chen include Rutgers University.
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Journal ArticleDOI
Autophagy Suppresses Tumorigenesis through Elimination of p62
Robin Mathew,Cristina M. Karp,Brian Beaudoin,Brian Beaudoin,Nhan Vuong,Guanghua Chen,Hsin-Yi Chen,Kevin Bray,Anupama Reddy,Gyan Bhanot,Céline Gélinas,Céline Gélinas,Robert S. DiPaola,Vassiliki Karantza-Wadsworth,Eileen White +14 more
TL;DR: Defective autophagy is a mechanism for p62 upregulation commonly observed in human tumors that contributes directly to tumorigenesis likely by perturbing the signal transduction adaptor function of p62-controlling pathways critical for oncogenesis.
Journal ArticleDOI
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
Jessie Yanxiang Guo,Hsin-Yi Chen,Robin Mathew,Jing Fan,Anne M. Strohecker,Gizem Karsli-Uzunbas,Jurre J. Kamphorst,Guanghua Chen,Johanna M.S. Lemons,Vassiliki Karantza,Hilary A. Coller,Hilary A. Coller,Robert S. DiPaola,Céline Gélinas,Céline Gélinas,Joshua D. Rabinowitz,Eileen White +16 more
TL;DR: This "autophagy addiction" suggests that targeting autophagy and mitochondrial metabolism are valuable new approaches to treat these aggressive cancers.
Journal ArticleDOI
Concurrent MEK2 Mutation and BRAF Amplification Confer Resistance to BRAF and MEK Inhibitors in Melanoma
Jessie Villanueva,Jeffrey R. Infante,Clemens Krepler,Patricia Reyes-Uribe,Minu Samanta,Hsin-Yi Chen,Bin Li,Rolf Swoboda,Melissa Wilson,Adina Vultur,Mizuho Fukunaba-Kalabis,Bradley Wubbenhorst,Thomas Y. Chen,Qin Liu,Katrin Sproesser,Douglas J. DeMarini,Tona M. Gilmer,Anne-Marie Martin,Ronen Marmorstein,David C. Schultz,David W. Speicher,Giorgos C. Karakousis,Wei Xu,Ravi K. Amaravadi,Xiaowei Xu,Lynn M. Schuchter,Meenhard Herlyn,Katherine L. Nathanson +27 more
TL;DR: A de novo MEK2-Q60P mutation and BRAF gain in a melanoma from a patient who progressed on the MEK inhibitor trametinib and did not respond to the BRAF inhibitor dabrafenib is reported.
Journal ArticleDOI
Role of Autophagy in Cancer Prevention
Hsin-Yi Chen,Eileen White +1 more
TL;DR: These findings revealed the concept that aggressive cancers can be addicted to autophagy for survival, and autophagic activity emerges as a critical factor in the development and progression of diseases associated with increased cancer risk as well as in different stages of cancer.
Journal ArticleDOI
Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition.
Kevin Bray,Robin Mathew,Alexandria Lau,Jurre J. Kamphorst,Jing Fan,James J. Chen,Hsin-Yi Chen,Anahita Ghavami,M. N. Stein,Robert S. DiPaola,Donna D. Zhang,Joshua D. Rabinowitz,Eileen White,Eileen White +13 more
TL;DR: It is shown that autophagy is a resistance mechanism of human renal cell carcinoma (RCC) cell lines to mTOR inhibitors, which leads to an imbalance between ROS production and defense, causing necroptosis that may enhance cancer treatment efficacy.