C
Ch. Huber
Researcher at University of Innsbruck
Publications - 68
Citations - 2908
Ch. Huber is an academic researcher from University of Innsbruck. The author has contributed to research in topics: Neopterin & Alpha interferon. The author has an hindex of 23, co-authored 68 publications receiving 2871 citations.
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Journal ArticleDOI
Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma.
Ch. Huber,J R Batchelor,Dietmar Fuchs,Arno Hausen,A. Lang,Dietger Niederwieser,Gilbert Reibnegger,P. Swetly,Jakob Troppmair,H. Wachter +9 more
TL;DR: It is demonstrated that macrophages stimulated with supernatant from activated T cells release large amounts of neopterin into culture supernatants, indicating that a metabolic pathway so far exclusively known in context with the generation of an essential cofactor of neurotransmitter-synthesis during immune responses is also activated in M phi under stringent control by immune IFN-like lymphokines.
Journal Article
Pteridines as a new marker to detect human T cells activated by allogeneic or modified self major histocompatibility complex (MHC) determinants.
Ch. Huber,Dietmar Fuchs,Arno Hausen,Raimund Margreiter,Gilbert Reibnegger,M. Spielberger,H. Wachter +6 more
TL;DR: It appears that the production of these PT is primarily a feature of activated T cells involved in the control of self integrity, and was excreted via the urine during allograft rejection and viral infections.
Journal ArticleDOI
Neopterin as a new biochemical marker for diagnosis of allograft rejection. Experience based upon evaluation of 100 consecutive cases.
Raimund Margreiter,Dietmar Fuchs,Arno Hausen,Ch. Huber,Gilbert Reibnegger,M. Spielberger,H. Wachter +6 more
TL;DR: It appears that daily assessment of urinary neopterin levels represents a useful tool for biochemical detection of immunological complications in allograft recipients.
Journal Article
Induction of circulating IL-1 receptor antagonist by IFN treatment.
H Tilg,James W. Mier,Wolfgang Vogel,Walter E. Aulitzky,Christian J. Wiedermann,Edouard Vannier,Ch. Huber,Charles A. Dinarello +7 more
TL;DR: The induction of IL-1Ra may contribute to the antiviral, anti-inflammatory, and antiproliferative effects of IFN.
Journal ArticleDOI
Rejection, after a slightly prolonged survival time, of Langerhans cell-free allogeneic cultured epidermis used for wound coverage in humans.
Josef Auböck,Eveline U. Irschick,Nikolaus Romani,P Kompatscher,R Höpfl,Manfred Herold,Gerold Schuler,M Bauer,Ch. Huber,Peter Fritsch +9 more
TL;DR: Grafting of allogeneic CE does not lead to permanent but to slightly prolonged graft survival, and limiting dilution analysis in 2 out of 4 allograft recipients revealed a considerable increase of circulating donor-specific cytotoxic T cell precursors during graft rejection.