H. Wachter

TL;DR: It is demonstrated that macrophages stimulated with supernatant from activated T cells release large amounts of neopterin into culture supernatants, indicating that a metabolic pathway so far exclusively known in context with the generation of an essential cofactor of neurotransmitter-synthesis during immune responses is also activated in M phi under stringent control by immune IFN-like lymphokines.

TL;DR: A novel role of NO is described as a signaling molecule in post‐transcriptional gene regulation and a regulatory connection between the NO/NOS pathway and cellular iron metabolism is identified.

TL;DR: The results show that intracellular concentrations of tetrahydrobiopterin control the amount of NO2- and NO3- produced in situ and suggest that the role of cytokine-induced tetrahytochemical synthesis is to provide cells with the active cofactor for production of nitrogen oxides.

TL;DR: Infiltration of endothelial cells by Ca2+ influx leads to increased intracellular levels of cGMP, and cytokines indirectly stimulate the activity of constitutive NO synthase in HUVEC by upregulating production of the cofactor tetrahydrobiopterin.

TL;DR: Upon interferon-gamma treatment, GTP-cyclohydrolase I activity is increased 7- to 40-fold, whereas 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase activities, which are constitutively present in all four investigated cells, remain unchanged.